Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.45 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.40 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.40 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4973263 | 0.85 | ENPP2 (0.36) | ENPP2ORAI1ORAI2ORAI3TTR | |
| SCHEMBL29427098 | 0.83 | ENPP2 (0.63) | ENPP2ORAI1ORAI2ORAI3MAPT | |
| SCHEMBL126401 | 0.83 | ENPP2 (0.63) | ENPP2ORAI1ORAI2ORAI3MAPT | |
| SCHEMBL29375771 | 0.76 | TSHR (0.48) | ENPP2TTRMAPTKMT2AMEN1 | |
| SCHEMBL41990 | 0.76 | TSHR (0.48) | ENPP2TTRMAPTKMT2AMEN1 | |
| SCHEMBL29644544 | 0.72 | ENPP2 (0.52) | ENPP2ORAI1ORAI2ORAI3TTR | |
| SCHEMBL385535 | 0.72 | ENPP2 (0.52) | ENPP2ORAI1ORAI2ORAI3TTR | |
| SCHEMBL29470875 | 0.70 | ENPP2 (0.48) | ENPP2ORAI1ORAI2ORAI3LMNA | |
| SCHEMBL1445093 | 0.70 | ENPP2 (0.48) | ENPP2ORAI1ORAI2ORAI3LMNA | |
| SCHEMBL22683580 | 0.70 | ENPP2 (0.44) | ENPP2ORAI1ORAI2ORAI3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979335-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007082808-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | disclosed |