Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.36 |
| ▸ | TTR | P02766 | 2/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.36 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.36 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4973256 | 0.85 | ENPP2 (0.45) | ENPP2TTRORAI1ORAI2ORAI3 | |
| SCHEMBL29427098 | 0.71 | ENPP2 (0.63) | ENPP2ORAI1ORAI2ORAI3MAPT | |
| SCHEMBL15701857 | 0.71 | TSHR (0.41) | TTRMAPTKMT2AMEN1CYP3A4 | |
| SCHEMBL126401 | 0.71 | ENPP2 (0.63) | ENPP2ORAI1ORAI2ORAI3MAPT | |
| SCHEMBL23077788 | 0.70 | ENPP2 (0.45) | ENPP2ORAI1ORAI2ORAI3ACHE | |
| SCHEMBL7772580 | 0.68 | KDM4E (0.50) | ENPP2ORAI1ORAI2ORAI3MAPT | |
| SCHEMBL19204646 | 0.65 | TRPV4 (0.44) | ENPP2TTRORAI1ORAI2ORAI3 | |
| SCHEMBL29644544 | 0.65 | ENPP2 (0.52) | ENPP2TTRORAI1ORAI2ORAI3 | |
| SCHEMBL385535 | 0.65 | ENPP2 (0.52) | ENPP2TTRORAI1ORAI2ORAI3 | |
| SCHEMBL1728265 | 0.64 | CA12 (0.46) | MAPTKDM4ECYP3A4ALOX15LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979335-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007082808-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | disclosed |