SCHEMBL4973483

SCHEMBL4973483

COC(=O)NCCO[C@@H](c1ccc(F)c(Cl)c1)[C@@H]1CCCN(C(C)(C)C)C1

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
REN P00797 20/20 0.53
CYP3A4 P08684 3/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3965440 0.88 REN (0.62) RENCYP3A4
SCHEMBL2329895 0.87 REN (0.58) RENCYP3A4
SCHEMBL2329887 0.87 REN (0.58) RENCYP3A4
SCHEMBL2329892 0.87 REN (0.58) RENCYP3A4
SCHEMBL4971684 0.87 REN (0.51) RENCYP3A4
SCHEMBL4974117 0.84 SLC6A2 (0.40) RENCYP3A4
SCHEMBL4972485 0.83 REN (0.61) RENCYP3A4
SCHEMBL4972222 0.82 REN (0.52) RENCYP3A4
SCHEMBL12443092 0.80 SLC6A2 (0.47) RENCYP3A4
SCHEMBL4971174 0.79 SLC6A3 (0.36) REN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1966139-A1 ASPARTIC PROTEASE INHIBITORS Vitae Pharmaceuticals, Inc. (US) 2008-09-10 EP disclosed
WO-2007070201-A1 ASPARTIC PROTEASE INHIBITORS VITAE PHARMACEUTICALS, INC. (US) 2007-06-21 WO disclosed