Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | NAAA | Q02083 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972806 | 0.96 | KMT2A (0.60) | KMT2AMEN1NAAAL3MBTL1TSHR | |
| SCHEMBL10270503 | 0.84 | NPC1 (0.58) | KMT2AMEN1L3MBTL1LMNACYP1A2 | |
| SCHEMBL4977230 | 0.79 | HPGD (0.52) | KMT2AMEN1L3MBTL1TSHRLMNA | |
| SCHEMBL4974356 | 0.78 | ALDH1A1 (0.44) | KMT2ATSHRLMNACYP1A2CYP2C9 | |
| SCHEMBL4979507 | 0.76 | MTNR1A (0.52) | KMT2AMEN1TSHRLMNABRD4 | |
| SCHEMBL10271249 | 0.75 | HPGD (0.54) | KMT2AMEN1L3MBTL1TSHRLMNA | |
| SCHEMBL10702177 | 0.75 | PDIA6 (0.56) | KMT2AMEN1L3MBTL1TSHRHTT | |
| SCHEMBL10271069 | 0.74 | CARM1 (0.46) | KMT2AL3MBTL1TSHRLMNACYP1A2 | |
| SCHEMBL11650358 | 0.73 | PDIA6 (0.54) | KMT2AMEN1L3MBTL1TSHRHTT | |
| SCHEMBL10870020 | 0.73 | PDIA6 (0.54) | KMT2AMEN1L3MBTL1TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | VHL, TP53, ASAH2 | KMT2A 2886/4885MEN1 256/4885NAAA 2927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.