Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 8/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.60 |
| ▸ | BRAF | P15056 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | LTA4H | P09960 | 1/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.57 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.57 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11926736 | 0.88 | KDM4E (0.65) | EPHX2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL7862109 | 0.83 | KDR (0.63) | EPHX2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL1801810 | 0.83 | CD274 (0.62) | EPHX2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL5943713 | 0.83 | KCNA5 (0.55) | KDM4ELTA4H | |
| SCHEMBL4014247 | 0.82 | EPHX2 (0.79) | EPHX2ALDH1A1RAB9ALTA4H | |
| SCHEMBL4256144 | 0.82 | EPHX2 (1.00) | EPHX2 | |
| SCHEMBL16178361 | 0.82 | EPHX2 (0.57) | EPHX2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL31289932 | 0.82 | EPHX2 (0.65) | EPHX2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL991354 | 0.82 | ALDH1A1 (0.76) | KDM4EALDH1A1GAASMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL10768966 | 0.82 | EPHX2 (0.57) | EPHX2KDM4EALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991547-A2 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PHARMACOPEIA, INC. (US) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007104053-A2 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PHARMACOPEIA, INC. (US) | 2007-09-13 | — | — | WO | disclosed |