⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5525076 | 0.81 | ALOX15 (0.33) | — | |
| SCHEMBL4974385 | 0.81 | FAAH (0.41) | — | |
| SCHEMBL5527923 | 0.79 | — | — | |
| SCHEMBL4976239 | 0.78 | ALDH1A1 (0.32) | — | |
| SCHEMBL17499016 | 0.65 | — | — | |
| SCHEMBL27472108 | 0.65 | — | — | |
| SCHEMBL27857479 | 0.65 | MGAM (0.46) | — | |
| SCHEMBL921532 | 0.64 | — | — | |
| SCHEMBL5973794 | 0.62 | — | — | |
| SCHEMBL16972287 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685114-B1 | ANTIBACTERIAL AND/OR ANTIPROTOZOAL NITROIMIDAZOLE DERIVATIVE COMPOUNDS WITH UREASE INHIBITOR ACTIVITY, PROCESS FOR PREPARING THESE COMPOUNDS AND USE IN PHARMACEUTICAL COMPOSITIONS AND MEDICINES. | EMS SA (BR) | 2008-10-15 | — | — | EP | claimed |
| US-20070072929-A1 | Antibacterial and/or antiprotozoal nitromidazole derivative compounds with urease inhibitor activity, process for preparing these compounds and use in pharmaceutical compositions and medicines | EMS S.A. (BR) | 2007-03-29 | — | — | US | claimed |
| EP-1685114-A2 | ANTIBACTERIAL AND/OR ANTIPROTOZOAL NITROIMIDAZOLE DERIVATIVE COMPOUNDS WITH UREASE INHIBITOR ACTIVITY, PROCESS FOR PREPARING THESE COMPOUNDS AND USE IN PHARMACEUTICAL COMPOSITIONS AND MEDICINES. | EMS S.A. (BR) | 2006-08-02 | — | — | EP | claimed |
| WO-2005041853-A2 | ANTIBACTERIAL AND/OR ANTIPROTOZOAL NITROIMIDAZOLE DERIVATIVE COMPOUNDS WITH UREASE INHIBITOR ACTIVITY, PROCESS FOR PREPARING THESE COMPOUNDS AND USE IN PHARMACEUTICAL COMPOSITIONS AND MEDICINES. | EMS S.A. (BR) | 2005-05-12 | — | — | WO | claimed |
| EP-1685114-B1 | ANTIBACTERIAL AND/OR ANTIPROTOZOAL NITROIMIDAZOLE DERIVATIVE COMPOUNDS WITH UREASE INHIBITOR ACTIVITY, PROCESS FOR PREPARING THESE COMPOUNDS AND USE IN PHARMACEUTICAL COMPOSITIONS AND MEDICINES. | EMS SA (BR) | 2008-10-15 | — | — | EP | disclosed |