Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 7/20 | 0.65 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | CYP27A1 | Q02318 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14061927 | 1.00 | MIF (0.65) | MIFCYP26A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL14137061 | 1.00 | MIF (0.65) | MIFCYP26A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3018271 | 0.91 | MIF (0.57) | MIFCYP26A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9391395 | 0.91 | MIF (0.57) | MIFCYP26A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3018274 | 0.91 | MIF (0.57) | MIFCYP26A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL11458794 | 0.87 | MIF (0.61) | MIFCYP26A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL12760787 | 0.84 | MIF (0.67) | MIFCYP26A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6361514 | 0.84 | MIF (0.67) | MIFCYP26A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3450462 | 0.83 | CYP19A1 (0.56) | MIFCYP26A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3450465 | 0.83 | CYP19A1 (0.56) | MIFCYP26A1SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2916839-B1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2017-10-11 | — | — | EP | disclosed |
| US-9624174-B2 | Compounds as diacylglycerol acyltransferase inhibitors | GLAXOSMITHKLINE LLC (US) | 2017-04-18 | — | — | US | disclosed |
| US-20160068487-A1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE LLC | 2016-03-10 | — | — | US | disclosed |
| EP-2723332-B1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2016-03-02 | — | — | EP | disclosed |
| US-9242929-B2 | Compounds as diacylglycerol acyltransferase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-01-26 | — | — | US | disclosed |
| US-9221766-B2 | Compounds as diacylglycerol acyltransferase inhibitors | GLAXOSMITHKLINE LLC (US) | 2015-12-29 | — | — | US | disclosed |
| US-20150307445-A1 | Novel Compounds as Diacylglycerol Acyltransferase Inhibitors | GlaxoSmith Kline Intellectual Property (No.2) Limited (GB) | 2015-10-29 | — | — | US | disclosed |
| EP-2916839-A2 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | Glaxosmithkline LLC (US) | 2015-09-16 | — | — | EP | disclosed |
| WO-2014074761-A2 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-05-15 | — | — | WO | disclosed |
| EP-2723332-A1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2014-04-30 | — | — | EP | disclosed |
| WO-2012162127-A1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-11-29 | — | — | WO | disclosed |
| EP-1270545-B1 | PROCESS FOR PRODUCING AMINE DERIVATIVES | TAKEDA PHARMACEUTICAL (JP) | 2008-11-05 | — | — | EP | disclosed |
| US-6784314-B2 | HAVING THE ACTION OF INHIBITING THE SECRETION AND ACCUMULATION OF AMYLOID BETA PROTEIN | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2004-08-31 | — | — | US | disclosed |
| US-20030139602-A1 | Process for producing amine derivatives | TAKEDA CHEMICAL INDUSTRIES LTD. (JP) | 2003-07-24 | — | — | US | disclosed |
| EP-1270545-A1 | PROCESS FOR PRODUCING AMINE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307445-A1 | Novel Compounds as Diacylglycerol Acyltransferase Inhibitors | DGAT1, DGAT2, LCAT | MIF 3756/4885CYP26A1 861/4885SMN1; SMN2 4859/4885 |
| US-20030139602-A1 | Process for producing amine derivatives | APP, BACE1, IAPP | MIF 4290/4885CYP26A1 2578/4885SMN1; SMN2 1882/4885 |
| US-20160068487-A1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | DGAT1, DGAT2, LCAT | MIF 3495/4885CYP26A1 508/4885SMN1; SMN2 4833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.