Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SCD | O00767 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2071657 | 0.87 | KCNQ2 (0.46) | MAPTLMNASCDALDH1A1HTT | |
| SCHEMBL27729107 | 0.84 | RAB9A (0.38) | MAPTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL30796593 | 0.83 | MEN1 (0.39) | MEN1KMT2ALMNAALDH1A1UTS2R | |
| SCHEMBL2071916 | 0.83 | MEN1 (0.39) | MEN1KMT2ALMNAALDH1A1UTS2R | |
| SCHEMBL27749765 | 0.83 | KDM4E (0.41) | MAPTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL27729021 | 0.78 | FFAR1 (0.45) | MAPTMEN1KMT2AALDH1A1HTT | |
| SCHEMBL27728996 | 0.76 | FFAR1 (0.55) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL2072355 | 0.74 | UTS2R (0.46) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL30794874 | 0.74 | UTS2R (0.46) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL27729239 | 0.72 | FFAR1 (0.52) | MAPTMEN1KMT2AALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1983974-A1 | USE OF KCNQ-OPENERS FOR TREATING OR REDUCING THE SYMPTOMS OF SCHIZOPHRENIA | H. Lundbeck A/S (DK) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007090409-A1 | USE OF KCNQ-OPENERS FOR THREATING OR REDUCING THE SYMPTOMS OF SCHIZOPHRENIA | H. LUNDBECK A/S (DK) | 2007-08-16 | — | — | WO | disclosed |