Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 5/20 | 0.58 |
| ▸ | KDM2A | Q9Y2K7 | 5/20 | 0.58 |
| ▸ | FOLH1 | Q04609 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | KDM5C | P41229 | 3/20 | 0.58 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.58 |
| ▸ | KDM6B | O15054 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.41 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4976282 | 0.88 | PHF8 (0.52) | PHF8KDM2AFOLH1KDM4EKDM5C | |
| SCHEMBL4976329 | 0.87 | SLC22A6 (0.46) | PHF8KDM2AFOLH1KDM4EKDM5C | |
| SCHEMBL4980094 | 0.76 | PHF8 (0.64) | PHF8KDM2AFOLH1KDM4EKDM5C | |
| SCHEMBL240068 | 0.75 | — | — | |
| SCHEMBL4977573 | 0.74 | SLC22A6 (0.52) | KDM4ELMNAALDH1A1MAPTMEN1 | |
| SCHEMBL4978244 | 0.74 | PHF8 (0.52) | PHF8KDM2AFOLH1KDM4EKDM5C | |
| SCHEMBL4976213 | 0.73 | PHF8 (0.58) | PHF8KDM2AFOLH1KDM4EKDM5C | |
| SCHEMBL4478714 | 0.72 | ALDH1A1 (0.33) | PHF8KDM2AFOLH1KDM4EKDM5C | |
| SCHEMBL4977396 | 0.72 | PHF8 (0.57) | PHF8KDM2AFOLH1KDM4EKDM5C | |
| SCHEMBL28461081 | 0.72 | PHF8 (0.57) | PHF8KDM2AFOLH1KDM4EKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685114-B1 | ANTIBACTERIAL AND/OR ANTIPROTOZOAL NITROIMIDAZOLE DERIVATIVE COMPOUNDS WITH UREASE INHIBITOR ACTIVITY, PROCESS FOR PREPARING THESE COMPOUNDS AND USE IN PHARMACEUTICAL COMPOSITIONS AND MEDICINES. | EMS SA (BR) | 2008-10-15 | — | — | EP | claimed |
| EP-1685114-A2 | ANTIBACTERIAL AND/OR ANTIPROTOZOAL NITROIMIDAZOLE DERIVATIVE COMPOUNDS WITH UREASE INHIBITOR ACTIVITY, PROCESS FOR PREPARING THESE COMPOUNDS AND USE IN PHARMACEUTICAL COMPOSITIONS AND MEDICINES. | EMS S.A. (BR) | 2006-08-02 | — | — | EP | claimed |
| WO-2005041853-A2 | ANTIBACTERIAL AND/OR ANTIPROTOZOAL NITROIMIDAZOLE DERIVATIVE COMPOUNDS WITH UREASE INHIBITOR ACTIVITY, PROCESS FOR PREPARING THESE COMPOUNDS AND USE IN PHARMACEUTICAL COMPOSITIONS AND MEDICINES. | EMS S.A. (BR) | 2005-05-12 | — | — | WO | claimed |