Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.85 |
| ▸ | MAPK13 | O15264 | 13/20 | 0.85 |
| ▸ | MAPK12 | P53778 | 13/20 | 0.85 |
| ▸ | MAPK11 | Q15759 | 13/20 | 0.85 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.85 |
| ▸ | RAF1 | P04049 | 5/20 | 0.85 |
| ▸ | GCGR | P47871 | 9/20 | 0.70 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.70 |
| ▸ | BRAF | P15056 | 2/20 | 0.66 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.60 |
| ▸ | FRK | P42685 | 2/20 | 0.60 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.60 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.60 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.60 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4552561 | 0.92 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL14283523 | 0.90 | MAPK13 (0.70) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL4553291 | 0.85 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL4553727 | 0.83 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL4552049 | 0.83 | ALOX5 (0.73) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL4552316 | 0.82 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL9195042 | 0.82 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL19868948 | 0.81 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL4551941 | 0.81 | MAPK13 (0.78) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL1629037 | 0.80 | MAPK13 (0.85) | MAPK14MAPK13MAPK12MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101426503-A | Compositions and methods of treatment for inhibiting kinase and/or HMG-COA reductase | PHARMIX CORP (US) | 2009-05-06 | — | — | CN | disclosed |
| US-20080021054-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2008-01-24 | — | — | US | disclosed |
| US-20080021054-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2008-01-24 | — | — | US | disclosed |
| US-20080021054-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2008-01-24 | — | — | US | disclosed |
| US-7199126-B2 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | PHARMIX CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| US-7199126-B2 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | PHARMIX CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| US-7199126-B2 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | PHARMIX CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| EP-1755607-A2 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | Pharmix Corporation (US) | 2007-02-28 | — | — | EP | disclosed |
| US-7183285-B2 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | PHARMIX CORP. (US) | 2007-02-27 | — | — | US | disclosed |
| US-7183285-B2 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | PHARMIX CORP. (US) | 2007-02-27 | — | — | US | disclosed |
| US-20070004758-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2007-01-04 | — | — | US | disclosed |
| US-20070004758-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2007-01-04 | — | — | US | disclosed |
| US-20070004758-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2007-01-04 | — | — | US | disclosed |
| US-20060084695-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2006-04-20 | — | — | US | disclosed |
| WO-2006028524-A2 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | PHARMIX CORPORATION (US) | 2006-03-16 | — | — | WO | disclosed |
| US-20050288306-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2005-12-29 | — | — | US | disclosed |
| US-20050282883-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2005-12-22 | — | — | US | disclosed |
| US-20050277653-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2005-12-15 | — | — | US | disclosed |
| US-20050272770-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2005-12-08 | — | — | US | disclosed |
| US-20050261354-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288306-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | MAPK14 198/4885MAPK13 189/4885MAPK12 69/4885 |
| US-20050282883-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | MAPK14 224/4885MAPK13 201/4885MAPK12 86/4885 |
| US-20060084695-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | MAPK14 198/4885MAPK13 189/4885MAPK12 69/4885 |
| US-20050277653-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | MAPK14 198/4885MAPK13 189/4885MAPK12 69/4885 |
| US-20070004758-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | HMGCR, HMGB3, HMGB2 | MAPK14 198/4885MAPK13 189/4885MAPK12 69/4885 |
| US-20050261354-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | MAPK14 198/4885MAPK13 189/4885MAPK12 69/4885 |
| US-20080021054-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | HMGCR, HMGB3, HMGB2 | MAPK14 198/4885MAPK13 189/4885MAPK12 69/4885 |
| US-20050272770-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | MAPK14 198/4885MAPK13 189/4885MAPK12 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.