Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CCKBR | P32239 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 3/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.41 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5007943 | 0.89 | TRPV4 (0.70) | TRPV4CCR1PSMB5F2MC4R | |
| SCHEMBL5007940 | 0.87 | TRPV4 (0.52) | TRPV4MAPK1CCKBRCCR1ITGB1 | |
| SCHEMBL13994351 | 0.83 | TRPV4 (0.65) | TRPV4MAPK1CCR1F2MC4R | |
| SCHEMBL4975527 | 0.82 | TRPV4 (0.66) | TRPV4MC4R | |
| SCHEMBL5004499 | 0.81 | TRPV4 (1.00) | TRPV4CCR1MC4R | |
| SCHEMBL29353598 | 0.81 | TRPV4 (1.00) | TRPV4CCR1MC4R | |
| SCHEMBL5007988 | 0.81 | TRPV4 (1.00) | TRPV4CCR1MC4R | |
| SCHEMBL28218477 | 0.81 | TRPV4 (1.00) | TRPV4CCR1MC4R | |
| SCHEMBL5007996 | 0.80 | TRPV4 (0.60) | TRPV4CCR1PSMB5F2MC4R | |
| SCHEMBL13994320 | 0.79 | TRPV4 (0.62) | TRPV4MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318945-A1 | Novel Compounds | CASILLAS LINDA N | 2008-12-25 | — | — | US | claimed |
| EP-1968590-A2 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007070865-A2 | PIPERAZINE COMPOUNDS AS AGONISTS OF TRPV4 CHANNEL RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-21 | — | — | WO | claimed |
| US-20080318945-A1 | Novel Compounds | CASILLAS LINDA N | 2008-12-25 | — | — | US | disclosed |
| US-20080318945-A1 | Novel Compounds | CASILLAS LINDA N | 2008-12-25 | — | — | US | disclosed |
| US-20080318945-A1 | Novel Compounds | CASILLAS LINDA N | 2008-12-25 | — | — | US | disclosed |
| EP-1968590-A2 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007070865-A2 | PIPERAZINE COMPOUNDS AS AGONISTS OF TRPV4 CHANNEL RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-21 | — | — | WO | disclosed |
| WO-2007070865-A2 | PIPERAZINE COMPOUNDS AS AGONISTS OF TRPV4 CHANNEL RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318945-A1 | Novel Compounds | TRPV4, TRPV1, TRPV3 | TRPV4 1/4885MAPK1 1612/4885CCKBR 441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.