Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | F2R | P25116 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL5506027 | 1.00 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL4977218 | 0.97 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL551263 | 0.87 | KMT2A (0.41) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL2161257 | 0.87 | KMT2A (0.41) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL4977222 | 0.86 | KMT2A (0.40) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL4976541 | 0.86 | KMT2A (0.40) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 | |
| Lithium Ion SCHEMBL4975146 | 0.85 | ITGB1 (0.40) | ALDH1A1KMT2AMEN1HPGD | |
| Lithium Ion SCHEMBL4978502 | 0.85 | MEN1 (0.37) | ALDH1A1SMN1; SMN2KMT2AMEN1MTNR1A | |
| Lithium Ion SCHEMBL5498755 | 0.85 | ITGB1 (0.40) | ALDH1A1KMT2AMEN1HPGD | |
| Lithium Ion SCHEMBL5499662 | 0.85 | MEN1 (0.37) | ALDH1A1SMN1; SMN2KMT2AMEN1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045727-A1 | Chiral 3-Halophthalic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045727-A1 | Chiral 3-Halophthalic Acid Derivatives | HDHD5, CRYZ, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | ALDH1A1 834/4885SMN1; SMN2 4855/4885MAPT 565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.