SCHEMBL4977897

SCHEMBL4977897

c1ccc(COc2ccc3cn[nH]c3c2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.58
MAPT P10636 3/20 0.53
KDM4E B2RXH2 3/20 0.53
MAPK1 P28482 2/20 0.53
NPSR1 Q6W5P4 2/20 0.53
HSP90AA1 P07900 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
CYP3A4 P08684 1/20 0.52
CDC7 O00311 2/20 0.52
FGFR1 P11362 2/20 0.51
FGFR2 P21802 1/20 0.50
FGFR3 P22607 1/20 0.50
MAOB P27338 4/20 0.48
NOD2 Q9HC29 1/20 0.48
CTSV O60911 1/20 0.48
CTSL P07711 1/20 0.48
MET P08581 1/20 0.48
PTGER1 P34995 1/20 0.47
ACHE P22303 1/20 0.47
ALDH1A1 P00352 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29463390 1.00 ALOX5 (0.58) ALOX5MAPTKDM4EMAPK1NPSR1
SCHEMBL2570284 0.88 CDC7 (0.61) ALOX5MAPTKDM4EMAPK1NPSR1
SCHEMBL18639993 0.85 MAOB (0.58) MAPTKDM4EMAPK1NPSR1TDP1
SCHEMBL31704405 0.82 FGFR1 (0.52) MAPTKDM4EMAPK1NPSR1HSP90AA1
SCHEMBL16711152 0.78 FGFR2 (0.71) MAPTKDM4ETDP1CYP3A4FGFR1
SCHEMBL13923957 0.78 FGFR1 (0.57) MAPTKDM4EHSP90AA1FGFR1FGFR2
SCHEMBL16874309 0.77 PTGER1 (0.51) MAPTMAPK1TDP1CDC7MAOB
SCHEMBL18441097 0.76 CDC7 (0.60) MAPTKDM4EMAPK1NPSR1HSP90AA1
SCHEMBL30025182 0.76 PTPN7 (0.55) MAPTKDM4EFGFR1FGFR2FGFR3
SCHEMBL19555316 0.76 PTPN7 (0.55) MAPTKDM4EFGFR1FGFR2FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020223273-A2 COMPOSITIONS AND METHODS FOR MODULATION OF ANTIBODY ACTIVITY INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER (US) 2020-11-05 WO claimed
US-12465637-B2 Compositions and methods for modulation of antibody activity INSTITUTE FOR CANCER RESEARCH (US) 2025-11-11 US disclosed
US-20240083853-A1 HSD17B13 INHIBITORS AND USES THEREOF FL2022-001, INC. 2024-03-14 US disclosed
CN-116600801-A HSD17B13 inhibitors and uses thereof FL2022-001公司 2023-08-15 CN disclosed
EP-4221701-A1 HSD17B13 INHIBITORS AND USES THEREOF FL2022-001, Inc. (US) 2023-08-09 EP disclosed
WO-2022197883-A1 COMPOSITIONS AND METHODS FOR MODULATION OF ANTIBODY ACTIVITY INSTITUTE FOR CANCER RESEARCH D/B/A (US) 2022-09-22 WO disclosed
US-20220175918-A1 COMPOSITIONS AND METHODS FOR MODULATION OF ANTIBODY ACTIVITY INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER 2022-06-09 US disclosed
WO-2022072491-A1 HSD17B13 INHIBITORS AND USES THEREOF METACRINE, INC. (US) 2022-04-07 WO disclosed
EP-3962926-A2 COMPOSITIONS AND METHODS FOR MODULATION OF ANTIBODY ACTIVITY Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center (US) 2022-03-09 EP disclosed
WO-2020223273-A2 COMPOSITIONS AND METHODS FOR MODULATION OF ANTIBODY ACTIVITY INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER (US) 2020-11-05 WO disclosed
US-20170342051-A1 INDOLE AND PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM LES LABORATOIRES SERVIER (FR) 2017-11-30 US disclosed
US-9765056-B2 Indole and pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them LES LABORATOIRES SERVIER (FR) 2017-09-19 US disclosed
EP-3168217-A1 NOVEL INDOLE AND PYRROLE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME Les Laboratoires Servier (FR) 2017-05-17 EP disclosed
EP-3027602-A1 NOVEL DERIVATIVES OF INDOLE AND PYRROLE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME Les Laboratoires Servier (FR) 2016-06-08 EP disclosed
US-20160152599-A1 INDOLE AND PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM LES LABORATOIRES SERVIER (FR) 2016-06-02 US disclosed
WO-2015011396-A1 NOVEL DERIVATIVES OF INDOLE AND PYRROLE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME LES LABORATOIRES SERVIER (FR) 2015-01-29 WO disclosed
EP-1991540-A1 CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS Amgen Inc. (US) 2008-11-19 EP disclosed
US-20070265270-A1 Cinnoline derivatives as phosphodiesterase 10 inhibitors MEMORY PHARMACEUTICALS CORPORATION 2007-11-15 US disclosed
WO-2007098214-A1 CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS AMGEN INC. (US) 2007-08-30 WO disclosed
WO-2002098861-A1 METHODS OF MAKING 1-(2-AMINOPROPYL)-6-HYDROXYINDAZOLE ALCON, INC. (CH) 2002-12-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170342051-A1 INDOLE AND PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM RB1, IDO1, BCL2A1 ALOX5 871/4885MAPT 1338/4885KDM4E 2371/4885
US-12465637-B2 Compositions and methods for modulation of antibody activity FCGR3B, FCGR2A, FCGRT ALOX5 1198/4885MAPT 2906/4885KDM4E 3317/4885
US-20160152599-A1 INDOLE AND PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM IDO1, IDO2, NFATC1 ALOX5 436/4885MAPT 1975/4885KDM4E 1742/4885
US-20070265270-A1 Cinnoline derivatives as phosphodiesterase 10 inhibitors PDE7A, PDE10A, PDE7B ALOX5 1340/4885MAPT 3301/4885KDM4E 2365/4885
US-20240083853-A1 HSD17B13 INHIBITORS AND USES THEREOF HSD17B3, HSD17B11, HSD17B1 ALOX5 731/4885MAPT 2694/4885KDM4E 3909/4885
US-20220175918-A1 COMPOSITIONS AND METHODS FOR MODULATION OF ANTIBODY ACTIVITY FCGR3B, FCGR2A, FCGRT ALOX5 1198/4885MAPT 2906/4885KDM4E 3317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.