Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A1 | P13866 | 5/20 | 0.42 |
| ▸ | SLC5A2 | P31639 | 5/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL498090 | 0.84 | SLC5A1 (0.46) | SLC5A1SLC5A2SCN9ATP53ALOX12 | |
| SCHEMBL2771605 | 0.82 | SCN9A (0.41) | SCN9AALDH1A1HCAR1ELANENTRK1 | |
| SCHEMBL498213 | 0.82 | SLC5A1 (0.47) | SLC5A1SLC5A2SCN9ATP53ALOX12 | |
| SCHEMBL497708 | 0.78 | SCN9A (0.41) | SCN9AALDH1A1HCAR1P2RX7KCNN4 | |
| SCHEMBL17843232 | 0.76 | HCAR1 (0.40) | SCN9AHCAR1P2RX7KCNN4HCRTR1 | |
| SCHEMBL20749504 | 0.74 | HCAR1 (0.37) | SCN9AHCAR1P2RX7KCNN4 | |
| SCHEMBL20817410 | 0.73 | PDE4B (0.43) | TP53ALOX12ALDH1A1TSHRKDM4E | |
| SCHEMBL15881976 | 0.72 | ALDH1A1 (0.46) | SLC5A1SLC5A2TP53ALOX12ALDH1A1 | |
| SCHEMBL22717498 | 0.71 | GAA (0.44) | SLC5A1SLC5A2TP53ALOX12ALDH1A1 | |
| SCHEMBL29574242 | 0.71 | GAA (0.44) | SLC5A1SLC5A2TP53ALOX12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106077-B2 | Compounds and methods for modulating FXR | ELI LILLY AND COMPANY (US) | 2012-01-31 | — | — | US | disclosed |
| EP-2029558-B1 | COMPOUNDS AND METHODS FOR MODULATING FXR | LILLY CO ELI (US) | 2010-03-10 | — | — | EP | disclosed |
| US-20090093524-A1 | COMPOUNDS AND METHODS FOR MODULATING FXR | JPMORGAN CHASE BANK, N.A., AS SUCCESSOR COLLATERAL AGENT | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093524-A1 | COMPOUNDS AND METHODS FOR MODULATING FXR | NR1H4, SLC10A1, FXR1 | SLC5A1 264/4885SLC5A2 321/4885SCN9A 3726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.