Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4259981 | 0.84 | ADAMTS5 (0.45) | POLBKMT2ANOTUMADAMTS5TP53 | |
| SCHEMBL4979242 | 0.82 | POLB (0.43) | POLBKMT2ANOTUMADAMTS5SMN1; SMN2 | |
| SCHEMBL4979616 | 0.77 | KMT2A (0.37) | POLBKMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL4263873 | 0.73 | AKR1B1 (0.42) | ADAMTS5MAPT | |
| SCHEMBL4976844 | 0.70 | KMT2A (0.38) | POLBKMT2AHTTMAPTCYP1A2 | |
| SCHEMBL4974510 | 0.69 | CNR1 (0.49) | POLBKMT2AADAMTS5ALDH1A1KDM4E | |
| SCHEMBL4979970 | 0.69 | AKR1B1 (0.41) | POLBKMT2AADAMTS5SMN1; SMN2ALDH1A1 | |
| SCHEMBL4979426 | 0.69 | CNR1 (0.51) | POLBKMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4979166 | 0.69 | CYP1A2 (0.39) | POLBKMT2AADAMTS5SMN1; SMN2HTT | |
| SCHEMBL4977919 | 0.67 | KMT2A (0.40) | POLBKMT2AALDH1A1KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984374-A1 | USE OF SPIRO Ý IMIDAZOLIDINE-4, 3'-INDOLE¨2, 2', 5' (1H) TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | AstraZeneca AB (SE) | 2008-10-29 | — | — | EP | claimed |
| WO-2007091946-A1 | USE OF SPIRO [ IMIDAZOLIDINE-4, 3'-INDOLE] 2, 2', 5' (1H) TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | WO | claimed |