Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485380 | 0.87 | CA1 (0.45) | GID4CA1CA2ADRA2AADRA1A | |
| SCHEMBL4969177 | 0.82 | ALDH1A1 (0.42) | GID4CA1CA2ADRA2AADRA1A | |
| SCHEMBL307442 | 0.75 | ALDH1A1 (0.46) | GID4ADRA2AADRA1ACYP2D6IDO1 | |
| SCHEMBL11676259 | 0.73 | ALDH1A1 (0.49) | GID4ADRA2AADRA1ACYP2D6IDO1 | |
| SCHEMBL29625707 | 0.73 | ALDH1A1 (0.49) | GID4ADRA2AADRA1ACYP2D6IDO1 | |
| SCHEMBL8355915 | 0.73 | GID4 (0.56) | GID4CA1CA2CA9ADRA2A | |
| Ammonia Solution, Strong SCHEMBL27946685 | 0.72 | ALDH1A1 (0.48) | GID4ADRA2AADRA1ACYP2D6IDO1 | |
| SCHEMBL29209214 | 0.71 | GID4 (0.50) | GID4ADRA2AADRA1ACYP2D6IDO1 | |
| SCHEMBL30186198 | 0.71 | GID4 (0.50) | GID4ADRA2AADRA1ACYP2D6IDO1 | |
| SCHEMBL29853558 | 0.70 | GID4 (0.52) | GID4ADRA2AADRA1ACYP2D6IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888517-A1 | NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | AstraZeneca AB (SE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006126939-A1 | NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |