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Sugi Predict / Compounds / SCHEMBL307442

SCHEMBL307442

SCHEMBL307442

c1ccc2c(c1)CCCC2c1ccc2ccc3cccc4c5ccccc5c1c2c34

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.46
▸ HPGD P15428 2/20 0.46
▸ CYP1A2 P05177 2/20 0.46
▸ THRB P10828 1/20 0.46
▸ HSD17B10 Q99714 1/20 0.46
▸ GID4 Q8IVV7 1/20 0.43
▸ ADRA2A P08913 4/20 0.42
▸ ADRA1A P35348 2/20 0.42
▸ CYP2D6 P10635 2/20 0.42
▸ ADRA1D P25100 1/20 0.42
▸ ADRA1B P35368 1/20 0.42
▸ HTR1A P08908 1/20 0.42
▸ OPRM1 P35372 1/20 0.42
▸ MEN1 O00255 1/20 0.41
▸ BLM P54132 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ TAAR1 Q96RJ0 1/20 0.41
▸ KDM4E B2RXH2 2/20 0.41
▸ GAA P10253 1/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL307441 0.82 GID4 (0.40) ALDH1A1HPGDCYP1A2THRBHSD17B10
SCHEMBL11676259 0.82 ALDH1A1 (0.49) ALDH1A1HPGDCYP1A2HSD17B10GID4
SCHEMBL29625707 0.82 ALDH1A1 (0.49) ALDH1A1HPGDCYP1A2HSD17B10GID4
Ammonia Solution, Strong SCHEMBL27946685 0.80 ALDH1A1 (0.48) ALDH1A1HPGDCYP1A2HSD17B10GID4
SCHEMBL11442085 0.78 ALDH1A1 (0.44) ALDH1A1HPGDCYP1A2GID4ADRA2A
SCHEMBL4979258 0.75 GID4 (0.41) ALDH1A1GID4ADRA2AADRA1ACYP2D6
SCHEMBL29853558 0.75 GID4 (0.52) ALDH1A1HPGDGID4ADRA2AADRA1A
SCHEMBL28647083 0.74 KDM4E (0.49) ALDH1A1HPGDCYP1A2HSD17B10GID4
SCHEMBL29209214 0.73 GID4 (0.50) ALDH1A1GID4ADRA2AADRA1ACYP2D6
SCHEMBL30186198 0.73 GID4 (0.50) ALDH1A1GID4ADRA2AADRA1ACYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1917289-B1 MEMBRANES AND METHODS USEFUL FOR CAUSTIC APPLICATIONS GE OSMONICS INC (US) 2017-08-02 — — EP disclosed
US-8092918-B2 Modified with aryl residues terminally-linked to the insoluble branched polyamide matrix through sulfonamide bonds; separations in extreme high pH applications, at high temperatures, stable performance over time; commercial scale GE OSMONICS, INC. (US) 2012-01-10 — — US disclosed
US-7909179-B2 Modified with aryl residues terminally-linked to the insoluble branched polyamide matrix through sulfonamide bonds; separations in extreme high pH applications, at high temperatures, stable performance over time; commercial scale GE OSMONICS, INC. (US) 2011-03-22 — — US disclosed
US-7575687-B2 Modified with aryl residues terminally-linked to the insoluble branched polyamide matrix through sulfonamide bonds; separations in extreme high pH applications, at high temperatures, stable performance over time; commercial scale GE OSMONICS, INC. (US) 2009-08-18 — — US disclosed
US-20080277342-A1 POLYAMIDE MATRICES AND METHODS FOR THEIR PREPARATION AND USE GE OSMONICS, INC. 2008-11-13 — — US disclosed
EP-1917289-A1 MEMBRANES AND METHODS USEFUL FOR CAUSTIC APPLICATIONS GE Osmonics, Inc. (US) 2008-05-07 — — EP disclosed
US-20070039885-A1 Membranes and methods useful for caustic applications GE OSMONICS, INC. 2007-02-22 — — US disclosed
WO-2007022100-A1 MEMBRANES AND METHODS USEFUL FOR CAUSTIC APPLICATIONS GE OSMONICS, INC. (US) 2007-02-22 — — WO disclosed
US-20070039873-A1 Modified polyamide matrices and methods for their preparation GE OSMONICS, INC. 2007-02-22 — — US disclosed