Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SNRNP200 | O75643 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3950566 | 0.80 | AKR1B1 (0.42) | AKR1B1CYP1A2MAPTCYP2C19KMT2A | |
| SCHEMBL4254358 | 0.79 | AKR1B1 (0.50) | AKR1B1AKR1A1TRPA1 | |
| SCHEMBL3952571 | 0.76 | OPRL1 (0.43) | AKR1B1CYP1A2MAPTCYP2C19KMT2A | |
| SCHEMBL3957230 | 0.75 | ALDH1A1 (0.39) | AKR1B1CYP1A2MAPTCYP2C19KMT2A | |
| SCHEMBL4979970 | 0.74 | AKR1B1 (0.41) | AKR1B1CYP1A2CYP2C19KMT2ACNR1 | |
| SCHEMBL4979166 | 0.74 | CYP1A2 (0.39) | AKR1B1CYP1A2MAPTCYP2C19KMT2A | |
| SCHEMBL4979292 | 0.73 | CYP1A2 (0.43) | AKR1B1CYP1A2MAPTCYP2C19KMT2A | |
| SCHEMBL4976847 | 0.72 | TRAP1 (0.39) | AKR1B1CYP1A2MAPTCYP2C19KMT2A | |
| SCHEMBL4259941 | 0.70 | AKR1B1 (0.48) | AKR1B1AKR1A1 | |
| SCHEMBL4983724 | 0.69 | ALDH1A1 (0.41) | AKR1B1CASP6CNR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984374-A1 | USE OF SPIRO Ý IMIDAZOLIDINE-4, 3'-INDOLE¨2, 2', 5' (1H) TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | AstraZeneca AB (SE) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007091946-A1 | USE OF SPIRO [ IMIDAZOLIDINE-4, 3'-INDOLE] 2, 2', 5' (1H) TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | WO | disclosed |