Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SNRNP200 | O75643 | 7/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3950564 | 0.78 | CYP1A2 (0.43) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL3952569 | 0.74 | OPRM1 (0.44) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL3957233 | 0.74 | CYP1A2 (0.39) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL4979296 | 0.73 | AKR1B1 (0.41) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL2471653 | 0.72 | ADRA1B (0.38) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL4979964 | 0.72 | CYP1A2 (0.42) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL4979162 | 0.72 | CYP1A2 (0.42) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL5135636 | 0.71 | DAO (0.37) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL4976851 | 0.69 | TRAP1 (0.39) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL23835718 | 0.69 | CYP1A2 (0.50) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984374-A1 | USE OF SPIRO Ý IMIDAZOLIDINE-4, 3'-INDOLE¨2, 2', 5' (1H) TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | AstraZeneca AB (SE) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007091946-A1 | USE OF SPIRO [ IMIDAZOLIDINE-4, 3'-INDOLE] 2, 2', 5' (1H) TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | WO | disclosed |