Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4982441 | 0.89 | ALDH1A1 (0.60) | ALDH1A1PTPN1KDM4EFLT3MAPT | |
| SCHEMBL9730094 | 0.85 | ALDH1A1 (0.53) | ALDH1A1PTPN1KDM4EFLT3NPSR1 | |
| SCHEMBL7511970 | 0.81 | MAPT (0.62) | ALDH1A1KDM4ENPSR1MAPTHTT | |
| SCHEMBL1938254 | 0.76 | ALDH1A1 (0.64) | ALDH1A1PTPN1KDM4EFLT3KMT2A | |
| SCHEMBL24436737 | 0.76 | ALDH1A1 (0.58) | ALDH1A1PTPN1KDM4EFLT3MAPT | |
| Bicarbonate SCHEMBL28084451 | 0.75 | ALDH1A1 (0.49) | ALDH1A1PTPN1KDM4EFLT3MAPT | |
| SCHEMBL22215820 | 0.75 | KDM4E (0.57) | ALDH1A1KDM4EFLT3MAPTGAA | |
| Bicarbonate SCHEMBL28084450 | 0.74 | ALDH1A1 (0.48) | ALDH1A1PTPN1KDM4EFLT3NPSR1 | |
| SCHEMBL18614861 | 0.74 | GAA (0.70) | ALDH1A1KDM4EFLT3MAPTGAA | |
| SCHEMBL15447613 | 0.74 | KAT6A (0.49) | ALDH1A1PTPN1KDM4EFLT3NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
| EP-1847535-A1 | 1-(PIPERIDIN-4-YL)-1H-INDOLE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2007-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | TPH1, HTR1D, HTR1B | ALDH1A1 91/4885PTPN1 3204/4885KDM4E 1637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.