Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | LSS | P48449 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4979311 | 0.89 | ALDH1A1 (0.50) | ALDH1A1PTPN1FLT3KDM4EMEN1 | |
| SCHEMBL1938254 | 0.85 | ALDH1A1 (0.64) | ALDH1A1PTPN1FLT3KDM4ECYP3A4 | |
| SCHEMBL11653015 | 0.81 | NPC1 (0.60) | ALDH1A1MEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL1940000 | 0.80 | ALDH1A1 (0.58) | ALDH1A1PTPN1FLT3KDM4ETHRA | |
| SCHEMBL13924205 | 0.77 | FLT3 (0.55) | ALDH1A1PTPN1FLT3KDM4EMEN1 | |
| SCHEMBL9730094 | 0.76 | ALDH1A1 (0.53) | ALDH1A1PTPN1FLT3KDM4ETSHR | |
| SCHEMBL24436737 | 0.76 | ALDH1A1 (0.58) | ALDH1A1PTPN1FLT3KDM4EMEN1 | |
| SCHEMBL262359 | 0.76 | ALDH1A1 (0.60) | ALDH1A1PTPN1FLT3LSSKDM4E | |
| SCHEMBL22215820 | 0.75 | KDM4E (0.57) | ALDH1A1FLT3KDM4EMEN1LMNA | |
| SCHEMBL2902590 | 0.74 | FLT3 (0.66) | ALDH1A1PTPN1FLT3KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
| EP-1847535-A1 | 1-(PIPERIDIN-4-YL)-1H-INDOLE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2007-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | TPH1, HTR1D, HTR1B | ALDH1A1 91/4885PTPN1 3204/4885FLT3 628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.