Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 8/20 | 0.41 |
| ▸ | PNP | P00491 | 4/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HBB | P68871 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4982134 | 0.79 | LMNA (0.32) | KDM4EALDH1A1LMNAPMP22MAPT | |
| SCHEMBL4985811 | 0.76 | ALOX15 (0.37) | ALOX15ALDH1A1 | |
| SCHEMBL4980375 | 0.76 | — | — | |
| SCHEMBL4979719 | 0.73 | TYMS (0.37) | TYMSPNPAKR1B1 | |
| SCHEMBL4982663 | 0.63 | BCL2 (0.51) | TYMSPNPKDM4EALDH1A1LMNA | |
| SCHEMBL3180710 | 0.63 | CDK1 (0.52) | TYMSPNPMITFTP53THRB | |
| SCHEMBL9576699 | 0.62 | POLB (0.41) | KDM4EALDH1A1LMNAPMP22HSD17B10 | |
| SCHEMBL13833421 | 0.61 | TYMS (0.45) | TYMS | |
| SCHEMBL13833434 | 0.60 | TYMS (0.36) | TYMSPNPAKR1B1 | |
| SCHEMBL9653630 | 0.60 | NPSR1 (0.49) | TYMSPNPMITFTP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080108614-A1 | Substituted 2-Amino-Quinazolin-4-Cn Compounds for Use in the Treatment of Cns Disorders, Pain, Stroke, Addiction and Epilepsy, their Preparation and Use as Intermediates | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2008-05-08 | — | — | US | claimed |
| CN-101142195-A | Substituted 2-amino-quinazolin-4-on compoundsfor use in the treatment of C N S disorders, pain, stroke, addicition and epilepsy, their preparation and use as intermediates | ESTEVE LABOR DR (ES) | 2008-03-12 | — | — | CN | claimed |
| EP-1841746-A1 | SUBSTITUTED 2-AMINO-QUINAZOLIN-4-ON COMPOUNDSFOR USE IN THE TREATMENT OF CNS DISORDERS, PAIN, STROKE, ADDICITION AND EPILEPSY, THEIR PREPARATION AND USE AS INTERMEDIATES | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-10-10 | — | — | EP | claimed |
| WO-2006072588-A1 | SUBSTITUTED 2-AMINO-QUINAZOLIN-4-CN COMPOUNDS FOR USE IN THE TREATMENT OF CNS DISORDERS, PAIN, STROKE, ADDICTION AND EPILEPSY, THEIR PREAPARATION AND USE AS INTERMEDIATES | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2006-07-13 | — | — | WO | claimed |
| US-20080108614-A1 | Substituted 2-Amino-Quinazolin-4-Cn Compounds for Use in the Treatment of Cns Disorders, Pain, Stroke, Addiction and Epilepsy, their Preparation and Use as Intermediates | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2008-05-08 | — | — | US | disclosed |
| CN-101142195-A | Substituted 2-amino-quinazolin-4-on compoundsfor use in the treatment of C N S disorders, pain, stroke, addicition and epilepsy, their preparation and use as intermediates | ESTEVE LABOR DR (ES) | 2008-03-12 | — | — | CN | disclosed |
| EP-1841746-A1 | SUBSTITUTED 2-AMINO-QUINAZOLIN-4-ON COMPOUNDSFOR USE IN THE TREATMENT OF CNS DISORDERS, PAIN, STROKE, ADDICITION AND EPILEPSY, THEIR PREPARATION AND USE AS INTERMEDIATES | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006072588-A1 | SUBSTITUTED 2-AMINO-QUINAZOLIN-4-CN COMPOUNDS FOR USE IN THE TREATMENT OF CNS DISORDERS, PAIN, STROKE, ADDICTION AND EPILEPSY, THEIR PREAPARATION AND USE AS INTERMEDIATES | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108614-A1 | Substituted 2-Amino-Quinazolin-4-Cn Compounds for Use in the Treatment of Cns Disorders, Pain, Stroke, Addiction and Epilepsy, their Preparation and Use as Intermediates | CNR2, CNR1, GRIN2C | TYMS 3641/4885PNP 1892/4885MITF 4846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.