Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 18/20 | 0.36 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19417642 | 0.76 | TYMS (0.44) | TYMS | |
| SCHEMBL354546 | 0.73 | PARP1 (0.41) | — | |
| SCHEMBL13833428 | 0.72 | DHFR (0.41) | — | |
| SCHEMBL13833435 | 0.72 | XDH (0.42) | TYMS | |
| SCHEMBL13833421 | 0.70 | TYMS (0.45) | TYMS | |
| SCHEMBL1703866 | 0.61 | KDM4E (0.46) | TYMSPNPAKR1B1 | |
| SCHEMBL4979810 | 0.60 | TYMS (0.41) | TYMSPNPAKR1B1 | |
| SCHEMBL22227944 | 0.60 | TYMS (0.50) | TYMS | |
| SCHEMBL24704369 | 0.57 | DYRK1A (0.46) | TYMS | |
| SCHEMBL4446270 | 0.57 | PNP (0.66) | PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2707487-B1 | RIBOSWITCHES | UNIV MANCHESTER (GB) | 2017-10-04 | — | — | EP | disclosed |
| US-20140213779-A1 | RIBOSWITCHES | THE UNIVERSITY OF MANCHESTER (GB) | 2014-07-31 | — | — | US | disclosed |
| US-20140213779-A1 | RIBOSWITCHES | THE UNIVERSITY OF MANCHESTER (GB) | 2014-07-31 | — | — | US | disclosed |
| WO-2012153142-A2 | RIBOSWITCHES | THE UNIVERSITY OF MANCHESTER (GB) | 2012-11-15 | — | — | WO | disclosed |