Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 2/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.34 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.34 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16599817 | 0.73 | HTR2A (0.33) | LMNA | |
| SCHEMBL20017698 | 0.71 | HTR2A (0.35) | — | |
| SCHEMBL505429 | 0.69 | EDNRA (0.32) | L3MBTL1 | |
| SCHEMBL5170532 | 0.68 | POLB (0.35) | — | |
| SCHEMBL5149443 | 0.67 | HTR2A (0.39) | — | |
| SCHEMBL16429613 | 0.67 | KDM1A (0.31) | — | |
| SCHEMBL9851147 | 0.67 | NPC1 (0.37) | NPC1LMNASMN1; SMN2 | |
| SCHEMBL365626 | 0.67 | CHRNA7 (0.32) | — | |
| SCHEMBL3992251 | 0.67 | KDM1A (0.36) | — | |
| SCHEMBL17707789 | 0.66 | AKR1C1 (0.33) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892528-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING FLURBIPROFEN | Reckitt Benckiser Healthcare International Limited (GB) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014039939-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING FLURBIPROFEN | RECKITT BENCKISER HEALTHCARE INTERNATIONAL LIMITED (GB) | 2014-03-13 | — | — | WO | disclosed |
| US-20080051460-A1 | PHARMACEUTICAL METHODS, DOSING REGIMES AND DOSAGE FORMS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MYRIAD GENETICS, INCORPORATED (US) | 2008-02-28 | — | — | US | disclosed |
| US-20070293576-A1 | Pharmaceutical Methods, Dosing Regimes And Dosage Forms For The Treatment Of Alzheimer's Disease | MYRIAD GENETICS, INCORPORATED (US) | 2007-12-20 | — | — | US | disclosed |
| EP-0032620-B2 | Process for preparing therapeutic 2-arylpropionic acids and esters, and novel arylmethylmalonate esters | THE UPJOHN COMPANY (US) | 1987-02-04 | — | — | EP | disclosed |
| EP-0032620-B1 | Process for preparing therapeutic 2-arylpropionic acids and esters, and novel arylmethylmalonate esters | THE UPJOHN COMPANY (US) | 1984-05-30 | — | — | EP | disclosed |