Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.62 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.62 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.62 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.62 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.62 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.62 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.62 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4985481 | 0.85 | GRIN2D (0.68) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4980238 | 0.84 | SIGMAR1 (0.71) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL10825147 | 0.77 | SIGMAR1 (1.00) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6155527 | 0.73 | SIGMAR1 (0.69) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4979869 | 0.73 | SPHK1 (0.50) | LMNA | |
| Bromide SCHEMBL5461826 | 0.71 | SPHK1 (0.49) | LMNA | |
| SCHEMBL2281406 | 0.71 | SIGMAR1 (1.00) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1273372 | 0.71 | SIGMAR1 (1.00) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL10941147 | 0.71 | SIGMAR1 (0.67) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL242504 | 0.71 | CA2 (0.61) | LMNASLC6A2TDP1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7351743-B1 | Therapeutic guanidines | WYETH (US) | 2008-04-01 | — | — | US | disclosed |
| EP-0918460-A1 | METHODS OF TREATMENT OF EYE TRAUMA AND DISORDERS | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-06-02 | — | — | EP | disclosed |
| WO-1998004131-A1 | METHODS OF TREATMENT OF EYE TRAUMA AND DISORDERS | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1998-02-05 | — | — | WO | disclosed |
| EP-0751767-A4 | THERAPEUTIC GUANIDINES | CAMBRIDGE NEUROSCIENCE INC (US) | 1997-12-10 | — | — | EP | disclosed |
| EP-0751767-A1 | THERAPEUTIC GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1997-01-08 | — | — | EP | disclosed |
| WO-1995020950-A1 | THERAPEUTIC GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1995-08-10 | — | — | WO | disclosed |