Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | NNMT | P40261 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29090068 | 0.84 | MAPK8 (0.38) | MAPK8POLBL3MBTL1PARP1NNMT | |
| SCHEMBL29032297 | 0.84 | POLB (0.41) | MAPK8POLBL3MBTL1PARP1NNMT | |
| SCHEMBL29976932 | 0.83 | SCN9A (0.38) | SCN9APOLBL3MBTL1CYP3A4MEN1 | |
| SCHEMBL9780998 | 0.83 | SCN9A (0.44) | SCN9APARP1CYP3A4MEN1KMT2A | |
| SCHEMBL5803208 | 0.82 | POLB (0.49) | MAPK8POLBL3MBTL1PARP1NNMT | |
| SCHEMBL4638489 | 0.80 | PARP1 (0.46) | MAPK8PARP1NNMTNPC1RAB9A | |
| SCHEMBL4604668 | 0.78 | PARP1 (0.42) | MAPK8PARP1NNMTNPC1RAB9A | |
| SCHEMBL28094287 | 0.77 | SCN9A (0.48) | SCN9APOLBSMN1; SMN2 | |
| SCHEMBL5147480 | 0.77 | ALOX15 (0.42) | L3MBTL1NPC1RAB9ACYP3A4SMN1; SMN2 | |
| SCHEMBL29773094 | 0.77 | SCN9A (0.44) | SCN9APARP1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987022-A1 | PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES | Pfizer Products Inc. (US) | 2008-11-05 | — | — | EP | claimed |
| WO-2007091176-A1 | PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-08-16 | — | — | WO | claimed |