Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 5/20 | 0.68 |
| ▸ | SLCO1B1 | Q9Y6L6 | 4/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.68 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.68 |
| ▸ | RHOC | P08134 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | THRB | P10828 | 1/20 | 0.68 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.68 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.68 |
| ▸ | ABCC3 | O15438 | 2/20 | 0.64 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.64 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.64 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.60 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.60 |
| ▸ | PDE6D | O43924 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5150889 | 0.98 | HMGCR (0.70) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL14131058 | 0.94 | HMGCR (0.65) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL6318546 | 0.90 | HMGCR (0.60) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL14131031 | 0.89 | HMGCR (0.59) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL28541933 | 0.88 | HMGCR (0.78) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL28541931 | 0.88 | HMGCR (0.78) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL13766356 | 0.87 | HMGCR (0.66) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL6138508 | 0.86 | HMGCR (0.81) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL1032 | 0.86 | HMGCR (0.81) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL12073345 | 0.86 | HMGCR (0.72) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7399773-B2 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid and phenylamide | WARNER-LAMBERT COMPANY (US) | 2008-07-15 | — | — | US | disclosed |
| US-7371855-B2 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide | WARNER-LAMBERT COMPANY (US) | 2008-05-13 | — | — | US | disclosed |
| US-7361771-B2 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide | WARNER-LAMBERT COMPANY (US) | 2008-04-22 | — | — | US | disclosed |
| EP-1534704-B1 | PROCESS FOR PREPARING 5-(4-FLUOROPHENYL)-1-¬2-((2R,4R)-4-HYDROXY -6-OXO-TETRAHYDRO-PYRAN-2-YL)ETHYL|-2-ISOPROPYL-4-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID PHENYLAMIDE | WARNER LAMBERT CO (US) | 2007-08-01 | — | — | EP | disclosed |
| EP-1534704-B1 | PROCESS FOR PREPARING 5-(4-FLUOROPHENYL)-1-¬2-((2R,4R)-4-HYDROXY -6-OXO-TETRAHYDRO-PYRAN-2-YL)ETHYL|-2-ISOPROPYL-4-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID PHENYLAMIDE | WARNER LAMBERT CO (US) | 2007-08-01 | — | — | EP | disclosed |
| EP-1353917-B1 | NOVEL PROCESS FOR THE SYNTHESIS OF 5-(4-FLUOROPHENYL)-1-(2-((2R, 4R)-4-HYDROXY -6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL)-2-ISOPROPYL-4-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID PHENYLAMIDE | WARNER LAMBERT CO (US) | 2007-03-28 | — | — | EP | disclosed |
| US-7183408-B2 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide | WARNER-LAMBERT COMPANY, LLC (US) | 2007-02-27 | — | — | US | disclosed |
| US-20070032663-A1 | Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide | BUTLER DONALD E | 2007-02-08 | — | — | US | disclosed |
| US-20070032664-A1 | Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide | BUTLER DONALD E | 2007-02-08 | — | — | US | disclosed |
| US-20070032662-A1 | Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrole-3-carboxylic acid and phenylamide | BUTLER DONALD E | 2007-02-08 | — | — | US | disclosed |
| US-20040220254-A1 | Process for preparing 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl) ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide | NELSON JADE D (US) | 2004-11-04 | — | — | US | disclosed |
| US-6777560-B2 | Process for preparing 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide | WARNER-LAMBERT COMPANY | 2004-08-17 | — | — | US | disclosed |
| US-20040068121-A1 | Process for preparing 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide | NELSON JADE D (US) | 2004-04-08 | — | — | US | disclosed |
| WO-2004014896-A1 | PROCESS FOR PREPARING 5-(4-FLUOROPHENYL)-1-[2-((2R,4R)-4-HYDROXY -6-OXO-TETRAHYDRO-PYRAN-2-YL)ETHYL]-2-ISOPROPYL-4-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID PHENYLAMIDE | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |
| EP-1353917-A2 | NOVEL PROCESS FOR THE SYNTHESIS OF 5-(4-FLUOROPHENYL)-1-(2-((2R, 4R)-4-HYDROXY -6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL)-2-ISOPROPYL-4-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID PHENYLAMIDE | WARNER-LAMBERT COMPANY (US) | 2003-10-22 | — | — | EP | disclosed |
| US-20030195353-A1 | Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo- tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide | BUTLER DONALD EUGENE (US) | 2003-10-16 | — | — | US | disclosed |
| US-6545153-B1 | Anticholesterol agents; antilipemic agents | WARNER-LAMBERT COMPANY | 2003-04-08 | — | — | US | disclosed |
| US-6476235-B2 | CHEMICAL INTERMEDIATE; ANTICHOLESTEROL AGENTS, ANTILIPEMIC AGENTS | WARNER-LAMBERT COMPANY | 2002-11-05 | — | — | US | disclosed |
| US-20020133026-A1 | NOVEL PROCESS FOR THE SYNTHESIS OF 5-(4-FLUOROPHENYL)-1-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL]-2-ISOPROPYL-4-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID PHENYLAMIDE | BUTLER DONALD EUGENE (US) | 2002-09-19 | — | — | US | disclosed |
| WO-2002055519-A2 | NOVEL PROCESS FOR THE SYNTHESIS OF 5-(4-FLUOROPHENYL)-1-[2-((2R, 4R)-4-HYDROXY -6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL]-2-ISOPROPYL-4-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID PHENYLAMIDE | WARNER LAMBERT CO (US) | 2002-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032662-A1 | Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrole-3-carboxylic acid and phenylamide | PCCA, PAH, HPD | HMGCR 620/4885SLCO1B1 3814/4885ABCB11 4805/4885 |
| US-20030195353-A1 | Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo- tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide | PCCA, PAH, HPD | HMGCR 837/4885SLCO1B1 3776/4885ABCB11 4792/4885 |
| US-20020133026-A1 | NOVEL PROCESS FOR THE SYNTHESIS OF 5-(4-FLUOROPHENYL)-1-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL]-2-ISOPROPYL-4-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID PHENYLAMIDE | PCCA, PAH, HPD | HMGCR 995/4885SLCO1B1 3793/4885ABCB11 4789/4885 |
| US-20070032664-A1 | Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide | PAH, PCCA, HPD | HMGCR 1030/4885SLCO1B1 4058/4885ABCB11 4824/4885 |
| US-20040220254-A1 | Process for preparing 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl) ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide | HMGCR, ORAI1, RYR2 | HMGCR 1/4885SLCO1B1 640/4885ABCB11 3480/4885 |
| US-20040068121-A1 | Process for preparing 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide | HMGCR, ORAI1, RYR2 | HMGCR 1/4885SLCO1B1 724/4885ABCB11 3453/4885 |
| US-20070032663-A1 | Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide | PAH, PCCA, HPD | HMGCR 1030/4885SLCO1B1 4058/4885ABCB11 4824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.