Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.42 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.42 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4980575 | 1.00 | CYP19A1 (0.45) | CYP19A1EPHA2GPBAR1LMNAAKR1B10 | |
| SCHEMBL11520209 | 0.92 | CYP19A1 (0.47) | CYP19A1EPHA2GPBAR1LMNAAKR1B10 | |
| SCHEMBL1331512 | 0.92 | CYP19A1 (0.47) | CYP19A1EPHA2GPBAR1LMNAAKR1B10 | |
| SCHEMBL9623704 | 0.86 | CYP19A1 (0.46) | CYP19A1EPHA2GPBAR1LMNAAKR1B10 | |
| SCHEMBL9623701 | 0.86 | CYP19A1 (0.46) | CYP19A1EPHA2GPBAR1LMNAAKR1B10 | |
| SCHEMBL3710947 | 0.84 | CYP19A1 (0.49) | CYP19A1EPHA2GPBAR1LMNAAKR1B10 | |
| SCHEMBL3363331 | 0.84 | CYP19A1 (0.49) | CYP19A1EPHA2GPBAR1LMNAAKR1B10 | |
| SCHEMBL3363326 | 0.84 | CYP19A1 (0.49) | CYP19A1EPHA2GPBAR1LMNAAKR1B10 | |
| SCHEMBL3708014 | 0.84 | CYP19A1 (0.49) | CYP19A1EPHA2GPBAR1LMNAAKR1B10 | |
| SCHEMBL5447175 | 0.84 | CYP19A1 (0.49) | CYP19A1EPHA2GPBAR1LMNAAKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080027237-A1 | Processes for preparations of 9,11-epoxy steroids and intermediates useful therein | NG JOHN S | 2008-01-31 | — | — | US | disclosed |
| EP-1148061-B1 | Epoxidation process | SEARLE LLC (US) | 2007-10-17 | — | — | EP | disclosed |
| EP-0973791-B1 | PROCESS FOR THE PREPARATION OF AN EPOXY COMPOUND | SEARLE LLC (US) | 2007-06-20 | — | — | EP | disclosed |
| EP-1794177-A2 | PROCESS FOR PREPARING 7 -ALKOXYCARBONYL SUBSTITUTED STEROIDS | Pharmacia Corporation (US) | 2007-06-13 | — | — | EP | disclosed |
| US-20070060746-A1 | PROCESSES FOR PREPARATION OF 9,11 EPOXY STEROIDS AND INTERMEDIATES USEFUL THEREIN | G.D. SEARLE, LLC (FORMERLY NAMED G.D. SEARLE & CO.) | 2007-03-15 | — | — | US | disclosed |
| US-7129345-B2 | Keto-substituted steroid compounds | PHARMACIA CORPORATION (US) | 2006-10-31 | — | — | US | disclosed |
| US-7112669-B2 | Processes for preparation of 9,11-epoxy steroids and intermediates useful therein | PHARMACIA CORPORATION (OF PFIZER, INC.) (US) | 2006-09-26 | — | — | US | disclosed |
| US-7038040-B2 | Process for preparation of 9, 11-epoxy steroids and intermediates useful therein | G.D. SEARLE & CO. (US) | 2006-05-02 | — | — | US | disclosed |
| WO-2006032970-A2 | PROCESS FOR PREPARING 7α-ALKOXYCARBONYL SUBSTITUTED STEROIDS | PHARMACIA CORPORATION (US) | 2006-03-30 | — | — | WO | disclosed |
| US-20050272927-A1 | Process for the preparation of 9, 11 epoxy steroids | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-12-08 | — | — | US | disclosed |
| EP-1167380-A2 | 11.alpha.-hydroxy-steroid-4,6-dien-3-one compounds and a process for their preparation | G.D. Searle & Co. (US) | 2002-01-02 | — | — | EP | disclosed |
| US-6335441-B1 | 5β-cyano-substituted steroid compounds | G.D. SEARLE & CO. | 2002-01-01 | — | — | US | disclosed |
| US-6331622-B1 | Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein | G.D. SEARLE & CO. | 2001-12-18 | — | — | US | disclosed |
| EP-1148061-A2 | Process for preparation of 9, 11- epoxy steroids and intermediates useful therein | G.D. SEARLE & CO. (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6258946-B1 | CHEMICAL INTERMEDIATE FOR DIURETIC | G. D. SEARLE & CO. | 2001-07-10 | — | — | US | disclosed |
| US-6180780-B1 | STEROIDS AND INTERMEDIATES AS DIURETICS | G.D. SEARLE & CO. | 2001-01-30 | — | — | US | disclosed |
| EP-0973791-A2 | PROCESS FOR PREPARATION OF 7 ALPHA-CARBOXYL 9, 11-EPOXY STEROIDS AND INTERMEDIATES USEFUL THEREIN AND A GENERAL PROCESS FOR THE EPOXIDATION OF OLIFINIC DOUBLE BONDS | G.D. Searle & Co. (US) | 2000-01-26 | — | — | EP | disclosed |
| US-5981744-A | REMOVING AN 11-ALPHA LEAVING GROUP FROM STARTING COMPOUND TO GENERATE A DOUBLE BOND BETWEEN THE 9- AND 11-CARBON ATOMS | G. D. SEARLE AND CO. (US) | 1999-11-09 | — | — | US | disclosed |
| WO-1997021720-A2 | PROCESSES FOR PREPARATION OF 7 ALPHA-CARBOXYL 9,11-EPOXY STEROIDS AND INTERMEDIATES USEFUL THEREIN AND A GENERAL PROCESS FOR THE EPOXIDATION OF OLIFINIC DOUBLE BONDS | G.D. SEARLE AND CO. (US) | 1997-06-19 | — | — | WO | disclosed |
| US-4559332-A | 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof | CIBA GEIGY CORPORATION (US) | 1985-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272927-A1 | Process for the preparation of 9, 11 epoxy steroids | CYP11A1, CYP4A11, CYP11B1 | CYP19A1 24/4885EPHA2 3239/4885GPBAR1 1070/4885 |
| US-20080027237-A1 | Processes for preparations of 9,11-epoxy steroids and intermediates useful therein | CYP4A11, CYP11B1, CYP17A1 | CYP19A1 14/4885EPHA2 659/4885GPBAR1 497/4885 |
| US-20070060746-A1 | PROCESSES FOR PREPARATION OF 9,11 EPOXY STEROIDS AND INTERMEDIATES USEFUL THEREIN | DHCR7, CYP4A11, HSD11B1 | CYP19A1 184/4885EPHA2 445/4885GPBAR1 519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.