Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4988101 | 0.87 | HTT (0.46) | HCRTR2HCRTR1HTTTSHRUSP2 | |
| SCHEMBL4989543 | 0.85 | HPGD (0.45) | ALDH1A1L3MBTL1POLBGAAHPGD | |
| SCHEMBL4985375 | 0.83 | GRM5 (0.51) | ALDH1A1L3MBTL1HPGD | |
| SCHEMBL4989388 | 0.83 | MAPK1 (0.55) | HTTLMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL4986952 | 0.83 | ALDH1A1 (0.43) | TSHRMAPTKDM4EALDH1A1GAA | |
| SCHEMBL4988720 | 0.82 | HSD17B10 (0.41) | TSHRMAPTKDM4EALDH1A1GFER | |
| SCHEMBL4992436 | 0.81 | MAPK1 (0.47) | HTTLMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL4985162 | 0.80 | KDM4E (0.49) | TSHRKDM4EALDH1A1POLBGAA | |
| SCHEMBL4992491 | 0.79 | MAPT (0.40) | HTTLMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL4990959 | 0.78 | SMN1; SMN2 (0.50) | LMNAMAPTALDH1A1L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | RENOVIS, INC. | 2008-02-14 | — | — | US | claimed |
| US-7297700-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2007-11-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX2 | HSP90AB1 1175/4885HCRTR2 334/4885HCRTR1 321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.