⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14188880 | 0.84 | PDE2A (0.31) | — | |
| SCHEMBL4982293 | 0.76 | POLB (0.32) | — | |
| SCHEMBL20477853 | 0.71 | FFAR1 (0.30) | — | |
| SCHEMBL28452460 | 0.70 | GRM5 (0.36) | — | |
| SCHEMBL4983751 | 0.70 | TP53 (0.37) | — | |
| SCHEMBL14402984 | 0.67 | TOP2A (0.33) | — | |
| SCHEMBL3008315 | 0.67 | GABRA1 (0.30) | — | |
| SCHEMBL24667803 | 0.66 | DRD2 (0.32) | — | |
| SCHEMBL30716896 | 0.66 | DRD2 (0.32) | — | |
| SCHEMBL4984988 | 0.66 | DRD2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
| EP-1847535-A1 | 1-(PIPERIDIN-4-YL)-1H-INDOLE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2007-10-24 | — | — | EP | disclosed |
| EP-1847535-A1 | 1-(PIPERIDIN-4-YL)-1H-INDOLE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2007-10-24 | — | — | EP | disclosed |