Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Naphthalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.82 |
| ▸ | DAO | P14920 | 1/20 | 0.82 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.82 |
| ▸ | CES2 | O00748 | 3/20 | 0.67 |
| ▸ | CES1 | P23141 | 3/20 | 0.67 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 3/20 | 0.54 |
| ▸ | CA1 | P00915 | 3/20 | 0.54 |
| ▸ | CA2 | P00918 | 3/20 | 0.54 |
| ▸ | CA6 | P23280 | 3/20 | 0.54 |
| ▸ | CA9 | Q16790 | 3/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.52 |
| ▸ | CA3 | P07451 | 2/20 | 0.50 |
| ▸ | CA4 | P22748 | 2/20 | 0.50 |
| ▸ | CA5A | P35218 | 2/20 | 0.50 |
| ▸ | CA7 | P43166 | 2/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthalene SCHEMBL11360560 | 1.00 | TSHR (0.82) | TSHRDAONAPRTCES2CES1 | |
| Naphthalene SCHEMBL28954790 | 1.00 | TSHR (0.82) | TSHRDAONAPRTCES2CES1 | |
| Terephthalic Acid SCHEMBL548684 | 0.94 | TSHR (0.72) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL976149 | 0.91 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL137419 | 0.91 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL3966600 | 0.91 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL407365 | 0.91 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL160564 | 0.91 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL975929 | 0.91 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL7719037 | 0.91 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 191 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117843640-A | Ultra-low potential electrochemiluminescence carboxylesterase activity detection biosensor and kit | 河南大学 | 2024-04-09 | — | — | CN | claimed |
| CN-117430732-A | Catalyst component for propylene polymerization, preparation method thereof, catalyst and application | 中国石油化工股份有限公司 | 2024-01-23 | — | — | CN | claimed |
| CN-114426599-B | Catalyst component for preparing polyolefin, preparation method thereof, olefin polymerization catalyst and application thereof | 中国石油化工股份有限公司 | 2023-11-10 | — | — | CN | claimed |
| CN-113754801-B | Solid catalyst for preparing olefin polymer and solid catalyst system | 中国石油化工股份有限公司 | 2023-02-28 | — | — | CN | claimed |
| CN-113754803-B | Catalyst system and application thereof as catalyst for olefin polymerization | 中国石油化工股份有限公司 | 2023-02-24 | — | — | CN | claimed |
| CN-110536909-B | Method for producing propylene copolymers having a low VOC content | 格雷斯公司 | 2022-08-23 | — | — | CN | claimed |
| CN-110938161-B | Catalyst system for olefin polymerization and prepolymerized catalyst composition and use thereof | 中国石油化工股份有限公司 | 2022-05-24 | — | — | CN | claimed |
| CN-114426599-A | Catalyst component for preparing polyolefin, preparation method thereof, olefin polymerization catalyst and application thereof | 中国石油化工股份有限公司 | 2022-05-03 | — | — | CN | claimed |
| CN-114085301-A | Solid catalyst component for preparing olefin polymer and application thereof | 中国石油化工股份有限公司 | 2022-02-25 | — | — | CN | claimed |
| CN-113773423-A | Solid catalyst component for preparing olefin polymer and application thereof | 中国石油化工股份有限公司 | 2021-12-10 | — | — | CN | claimed |
| EP-2323968-B1 | INTERNAL DONOR FOR OLEFIN POLYMERIZATION CATALYSTS | BASF CORP (US) | 2013-03-27 | — | — | EP | claimed |
| US-8227370-B2 | High activity catalyst component for olefin polymerization and method of using the same | BASF CORPORATION (US) | 2012-07-24 | — | — | US | claimed |
| US-8211819-B2 | Internal and external donor compounds for olefin polymerization catalysts | BASF CORPORATION (US) | 2012-07-03 | — | — | US | claimed |
| US-20120116031-A1 | High Activity Catalyst Component for Olefin Polymerization and Method of Using the Same | BASF CORPORATION (US) | 2012-05-10 | — | — | US | claimed |
| JP-2011529888-A | — | — | 2011-12-15 | — | — | JP | claimed |
| US-8003558-B2 | Internal donor for olefin polymerization catalysts | BASF CORPORATION (US) | 2011-08-23 | — | — | US | claimed |
| US-20110152481-A1 | Internal and external donor compounds for olefin polymerization catalysts | BASF CATALYSTS LLC (US) | 2011-06-23 | — | — | US | claimed |
| EP-2323968-A1 | INTERNAL DONOR FOR OLEFIN POLYMERIZATION CATALYSTS | BASF Corporation (US) | 2011-05-25 | — | — | EP | claimed |
| US-20100029870-A1 | INTERNAL DONOR FOR OLEFIN POLYMERIZATION CATALYSTS | BASF CATALYSTS LLC (US) | 2010-02-04 | — | — | US | claimed |
| WO-2010014320-A1 | INTERNAL DONOR FOR OLEFIN POLYMERIZATION CATALYSTS | BASF CATALYSTS LLC (US) | 2010-02-04 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029870-A1 | INTERNAL DONOR FOR OLEFIN POLYMERIZATION CATALYSTS | TEC, DDT, DNTT | TSHR 3984/4885DAO 244/4885NAPRT 176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.