Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 4/20 | 0.41 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP4 | P49662 | 1/20 | 0.40 |
| ▸ | CASP5 | P51878 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936802 | 0.86 | MEN1 (0.51) | MEN1KMT2AALDH1A1MAPTCYP2D6 | |
| SCHEMBL937533 | 0.86 | SIGMAR1 (0.52) | ALDH1A1MAPTTSHR | |
| SCHEMBL937341 | 0.81 | FAAH (0.50) | FAAHMGLL | |
| SCHEMBL937262 | 0.80 | SCD (0.49) | FAAHMEN1KMT2AMGLL | |
| SCHEMBL936748 | 0.79 | MGLL (0.46) | FAAHMGLL | |
| SCHEMBL936764 | 0.78 | KDM4E (0.56) | MEN1KMT2AALDH1A1 | |
| SCHEMBL936973 | 0.78 | SCD (0.49) | FAAHMEN1KMT2AALDH1A1 | |
| SCHEMBL20566996 | 0.76 | FAAH (0.78) | FAAHMGLL | |
| SCHEMBL937146 | 0.75 | DRD4 (0.50) | KMT2AALDH1A1MAPTCASP1CASP4 | |
| SCHEMBL993579 | 0.74 | NPSR1 (0.56) | MEN1KMT2AALDH1A1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335658-B2 | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2008-02-26 | — | — | US | claimed |