Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2845228 | 0.82 | ALDH1A1 (0.53) | ALDH1A1GAAKDM4ESMN1; SMN2POLB | |
| SCHEMBL16884618 | 0.80 | POLB (0.46) | ALDH1A1GAAKDM4EIMPDH2IMPDH1 | |
| SCHEMBL11362823 | 0.78 | POLB (0.45) | ALDH1A1GAAKDM4EIMPDH2IMPDH1 | |
| SCHEMBL23860831 | 0.78 | POLB (0.45) | ALDH1A1GAAKDM4EIMPDH2IMPDH1 | |
| SCHEMBL29779908 | 0.78 | POLB (0.45) | ALDH1A1GAAKDM4EIMPDH2IMPDH1 | |
| SCHEMBL28338628 | 0.76 | ALDH1A1 (0.48) | ALDH1A1GAAKDM4ESMN1; SMN2POLB | |
| SCHEMBL18984961 | 0.76 | ALDH1A1 (0.48) | ALDH1A1GAAKDM4ESMN1; SMN2POLB | |
| SCHEMBL12327826 | 0.76 | ALDH1A1 (0.51) | ALDH1A1GAAKDM4ESMN1; SMN2POLB | |
| SCHEMBL2170193 | 0.76 | GABRA1 (0.43) | ALDH1A1GAAKDM4ESMN1; SMN2HPGD | |
| SCHEMBL2479613 | 0.75 | ALDH1A1 (0.52) | ALDH1A1GAAKDM4EPOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
| EP-1847535-A1 | 1-(PIPERIDIN-4-YL)-1H-INDOLE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2007-10-24 | — | — | EP | disclosed |
| US-6380436-B1 | REACTING 4-TRIFLUOROMETHYLBENZONITRILE WITH GRIGNARD REAGENT | SUN PHARMACEUTICAL INDUSTRIES LTD. (IN) | 2002-04-30 | — | — | US | disclosed |
| WO-1999058485-A1 | A PROCESS FOR THE SYNTHESIS OF ALKOXYALKYL (TRIFLUOROMETHYLPHENYL) METHANONES | SUN PHARMACEUTICALS INDUSTRIES LTD. (IN) | 1999-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | TPH1, HTR1D, HTR1B | ALDH1A1 91/4885GAA 4739/4885KDM4E 1637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.