Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 4/20 | 0.40 |
| ▸ | HTR2B | P41595 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476313 | 0.81 | KDM1A (0.52) | KDM1ABACE1HTR2CHTR2BSLC6A2 | |
| SCHEMBL13742600 | 0.81 | KDM1A (0.52) | KDM1ABACE1HTR2CHTR2BSLC6A2 | |
| SCHEMBL30681455 | 0.81 | KDM1A (0.52) | KDM1ABACE1HTR2CHTR2BSLC6A2 | |
| SCHEMBL4126357 | 0.81 | KDM1A (0.52) | KDM1ABACE1HTR2CHTR2BSLC6A2 | |
| SCHEMBL11313315 | 0.77 | POLB (0.51) | POLBTDP1GAASMN1; SMN2TSHR | |
| SCHEMBL21611525 | 0.77 | POLB (0.51) | POLBTDP1GAASMN1; SMN2TSHR | |
| SCHEMBL1817991 | 0.75 | BACE1 (0.61) | KDM1ABACE1HTR2CHTR2BSLC6A2 | |
| SCHEMBL1817989 | 0.75 | BACE1 (0.61) | KDM1ABACE1HTR2CHTR2BSLC6A2 | |
| SCHEMBL1817994 | 0.75 | BACE1 (0.61) | KDM1ABACE1HTR2CHTR2BSLC6A2 | |
| SCHEMBL13041182 | 0.72 | BACE1 (0.38) | KDM1AGAASMN1; SMN2BACE1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644326-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK CANADA INC (CA) | 2016-11-02 | — | — | EP | disclosed |
| US-7405229-B2 | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA & CO. (CA) | 2008-07-29 | — | — | US | disclosed |
| US-20070167635-A1 | Cathepsin cysteine protease inhibitors | MERCK CANADA INC. (CA) | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167635-A1 | Cathepsin cysteine protease inhibitors | CTSB, CTSS, CTSK | POLB 3109/4885TDP1 4503/4885KDM1A 2164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.