⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12522543 | 0.79 | NPSR1 (0.46) | — | |
| SCHEMBL31053510 | 0.78 | TPI1 (0.45) | — | |
| SCHEMBL103430 | 0.77 | — | — | |
| SCHEMBL19036894 | 0.76 | TPI1 (0.43) | — | |
| SCHEMBL18798882 | 0.76 | TPI1 (0.43) | — | |
| SCHEMBL166515 | 0.74 | — | — | |
| SCHEMBL10993476 | 0.74 | — | — | |
| SCHEMBL8582117 | 0.74 | — | — | |
| SCHEMBL2730627 | 0.74 | SPR (0.49) | — | |
| SCHEMBL8580583 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140173764-A9 | ROLE OF PROTEOGLYCANS IN DRUG DEPENDENCE | SANNA PIETRO P (US) | 2014-06-19 | — | — | US | disclosed |
| US-20120174240-A1 | ROLE OF PROTEOGLYCANS IN DRUG DEPENDENCE | SANNA PIETRO P (US) | 2012-07-05 | — | — | US | disclosed |
| EP-1982985-A2 | Method for manufacturing a purine derivative | Lonza AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| EP-1508565-B1 | Process for the preparation of optically active aminoalcohols | LONZA AG (CH) | 2008-08-13 | — | — | EP | disclosed |
| US-7358073-B2 | Process for the preparation of aminoalcohol derivatives and their further conversion to (1R, 4S)-4(2-amino-6-chloro-5-formamido-4- pyrimidinyl)-amino-2-cyclopentenyl-1-methanol | LONZA AG (CH) | 2008-04-15 | — | — | US | disclosed |
| US-7338945-B2 | Process for the preparation of aminoalcohol derivatives and their further conversion to (1R, 4S)-4(2-amino-6-chloro-5-formamido-4-pyrimidinyl)-amino-2-cyclopentenyl-1-methanol | LONZA AG (CH) | 2008-03-04 | — | — | US | disclosed |
| US-7229981-B2 | Process for the preparation of aminoalcohol derivatives and their further conversion to (1R,4S)-4-(2-amino-6-chloro-5-formamido-4-pyrimidinyl)-amino)-2-cyclopentenyl-1-methanol | LONZA AG (CH) | 2007-06-12 | — | — | US | disclosed |
| US-20070123545-A1 | PROCESS FOR THE PREPARATION OF AMINOALCOHOL DERIVATIVES AND THEIR FURTHER CONVERSION TO (1R, 4S)-4(2-AMINO-6-CHLORO-5-FORMAMIDO-4- PYRIMIDINYL)-AMINO-2-CYCLOPENTENYL-1-METHANOL | LONZA LTD. (CH) | 2007-05-31 | — | — | US | disclosed |
| US-20060211862-A1 | PROCESS FOR THE PREPARATION OF AMINOALCOHOL DERIVATIVES AND THEIR FURTHER CONVERSION TO (1R, 4S)-4(2-AMINO-6-CHLORO-5-FORMAMIDO-4- PYRIMIDINYL)-AMINO-2-CYCLOPENTENYL-1-METHANOL | LONZA INC. (US) | 2006-09-21 | — | — | US | disclosed |
| EP-1657243-A1 | Procedure for the production of amino alcohols | Lonza AG (CH) | 2006-05-17 | — | — | EP | disclosed |
| EP-1508565-A1 | Process for the preparation of optically active aminoalcohols | Lonza AG (CH) | 2005-02-23 | — | — | EP | disclosed |
| US-20040142436-A1 | Process for the preparation of aminoalcohol derivatives and their further conversion to (1R,4S)-4-(2-amino-6-chloro-5-formamido-4-pyrimidinyl)-amino)-2-cyclopentenyl-1-methanol | BRIEDEN WALTER (CH) | 2004-07-22 | — | — | US | disclosed |
| EP-1418170-A2 | Process for the preparation of optically active amino alcohols by optical resolution | Lonza AG (CH) | 2004-05-12 | — | — | EP | disclosed |
| US-6723868-B1 | REDUCING 2-AZABICYCLO(2.2.1)HEPT-5-EN-1-ONE WITH LITHIUM BOROHYDRIDE TO FORM 1-AMINO-4-(HYDROXYMETHYL)-2- CYCLOPENTENE | LONZA AG (CH) | 2004-04-20 | — | — | US | disclosed |
| US-6448402-B2 | REDUCTION OF 2-AZABICYCLO(2.2.1)HEPT-5-EN-3-ONE USING METAL HYRIDE | LONZA AG (CH) | 2002-09-10 | — | — | US | disclosed |
| US-20020010360-A1 | Process for the preparation of aminoalcohol derivatives and their further conversion to (1R, 4S)-4-((2-amino-6-chloro-5-formamido-4-pyrimidinyl)-amino)-2-cyclopentenyl-1- methanol | LONZA AG (CH) | 2002-01-24 | — | — | US | disclosed |
| EP-0926131-A2 | Process for the preparation of aminoalcohol derivatives and their further transformation zu (1R,4S)-4-((2-amino-6-chlor-5-formamido-4-pyrimidinyl)-amino)-2-cyclopenten-1-methanol | LONZA A.G. (CH) | 1999-06-30 | — | — | EP | disclosed |
| US-4064110-A | FROM 5-ALKOXYMETHYL-1,3,4-DIOXAZOL-2-ONES, ALKALI METAL CARBOXYLATE CATALYST | BAYER AKTIENGESELLSCHAFT (DT) | 1977-12-20 | — | — | US | disclosed |