Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15043735 | 0.87 | ALDH1A1 (0.39) | TSHRALDH1A1PTPN1CYP2C19NR1H2 | |
| SCHEMBL5012067 | 0.82 | TSHR (0.52) | TSHRALDH1A1PTPN1CYP2C19CYP1A2 | |
| SCHEMBL6680835 | 0.82 | ALDH1A1 (0.42) | TSHRALDH1A1PTPN1CYP2C19CYP1A2 | |
| SCHEMBL30788816 | 0.81 | ALDH1A1 (0.46) | TSHRALDH1A1PTPN1CYP2C19CA1 | |
| SCHEMBL5409516 | 0.76 | TAAR1 (0.48) | TSHRALDH1A1PTPN1CA1CA2 | |
| SCHEMBL11601071 | 0.76 | TSHR (0.46) | TSHRALDH1A1PTPN1CYP2C19CYP1A2 | |
| SCHEMBL507483 | 0.75 | TSHR (0.50) | TSHRALDH1A1PTPN1CYP2C19CYP1A2 | |
| SCHEMBL20984092 | 0.74 | ALDH1A1 (0.49) | TSHRALDH1A1PTPN1CYP2C19CYP1A2 | |
| SCHEMBL20919610 | 0.74 | ALDH1A1 (0.49) | TSHRALDH1A1PTPN1CYP2C19CYP1A2 | |
| SCHEMBL20919612 | 0.74 | ALDH1A1 (0.49) | TSHRALDH1A1PTPN1CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3856830-A1 | CURABLE FLUORINE-BASED ELASTOMER COMPOSITE AND CURED PRODUCT THEREOF | 3M Innovative Properties Company (US) | 2021-08-04 | — | — | EP | claimed |
| WO-2020065467-A1 | CURABLE FLUORINE-BASED ELASTOMER COMPOSITE AND CURED PRODUCT THEREOF | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2020-04-02 | — | — | WO | claimed |
| CN-103710393-B | Utilize the method preparing chiral alcohol containing small peptide class ionic liquid reaction system | JIANG University OF TECHNOLOGY (CN) | 2016-03-09 | — | — | CN | claimed |
| CN-105085189-A | Method for preparing -3, 5-bis (trifluoromethyl) phenethyl alcohol by asymmetric hydrogenation method | ENANTIOTECH CORP LTD | 2015-11-25 | — | — | CN | claimed |
| EP-3856830-A1 | CURABLE FLUORINE-BASED ELASTOMER COMPOSITE AND CURED PRODUCT THEREOF | 3M Innovative Properties Company (US) | 2021-08-04 | — | — | EP | disclosed |
| WO-2020065467-A1 | CURABLE FLUORINE-BASED ELASTOMER COMPOSITE AND CURED PRODUCT THEREOF | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2020-04-02 | — | — | WO | disclosed |
| CN-108624603-A | One kind (S)-carbonyl reductase and its encoding gene and application | 河北省科学院生物研究所 | 2018-10-09 | — | — | CN | disclosed |
| CN-105330517-A | Method for synthesizing 3,5-bis(trifluoromethyl) phenethyl alcohol | ENANTIOTECH CORP LTD | 2016-02-17 | — | — | CN | disclosed |
| CN-103421823-B | Come from the short-chain dehydrogenase of Lei Fusong Salmonella, encoding gene, carrier, engineering bacteria and application | JIANG University OF TECHNOLOGY (CN) | 2015-12-23 | — | — | CN | disclosed |
| CN-105085189-A | Method for preparing -3, 5-bis (trifluoromethyl) phenethyl alcohol by asymmetric hydrogenation method | ENANTIOTECH CORP LTD | 2015-11-25 | — | — | CN | disclosed |
| CN-102382780-B | Microbacterium oxydans and method for preparing chiral bis(trifluoromethyl) phenyl ethanol by using same | CHENGDU INST BIOLOGY CAS | 2013-02-13 | — | — | CN | disclosed |
| CN-102382780-B | Microbacterium oxydans and method for preparing chiral bis(trifluoromethyl) phenyl ethanol by using same | CHENGDU INST BIOLOGY CAS | 2013-02-13 | — | — | CN | disclosed |
| EP-1558243-A4 | TETRAHYDROPYRANYL CYCLOPENTYL BENZYLAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2006-11-02 | — | — | EP | disclosed |
| EP-1558250-A4 | GAMMA-AMINOAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2006-11-02 | — | — | EP | disclosed |
| US-20060116421-A1 | Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity | MERCK SHARP & DOHME CORP. | 2006-06-01 | — | — | US | disclosed |
| US-20050261325-A1 | Especially N-(3-carbonylamino3-substituted-propyl)spiro(indene- or indane-2,4'-piperidine derivatives, useful in treatment of inflammatory and immunoregulatory disorders, allergic diseases, atopic conditions, autoimmune disorders and atherosclerosis | MERCK SHARP & DOHME CORP. | 2005-11-24 | — | — | US | disclosed |
| EP-1558243-A2 | TETRAHYDROPYRANYL CYCLOPENTYL BENZYLAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| EP-1558250-A1 | GAMMA-AMINOAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004041279-A1 | GAMMA-AMINOAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2004-05-21 | — | — | WO | disclosed |
| WO-2004041161-A2 | TETRAHYDROPYRANYL CYCLOPENTYL BENZYLAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2004-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116421-A1 | Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity | CCR2, CCR1, CCR9 | TSHR 381/4885ALDH1A1 2478/4885PTPN1 1823/4885 |
| US-20050261325-A1 | Especially N-(3-carbonylamino3-substituted-propyl)spiro(indene- or indane-2,4'-piperidine derivatives, useful in treatment of inflammatory and immunoregulatory disorders, allergic diseases, atopic conditions, autoimmune disorders and atherosclerosis | CCR1, CCR3, CCR2 | TSHR 655/4885ALDH1A1 1345/4885PTPN1 1422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.