Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BRS3 | P32247 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | F12 | P00748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4989569 | 0.92 | ALDH1A1 (0.40) | KMT2AKDM4ENPC1ALDH1A1GAA | |
| SCHEMBL14296827 | 0.87 | KMT2A (0.38) | KMT2AKDM4ENPC1ALDH1A1GAA | |
| SCHEMBL14272249 | 0.87 | BRS3 (0.41) | KMT2AKDM4ENPC1ALDH1A1GAA | |
| SCHEMBL4985286 | 0.86 | KMT2A (0.43) | KMT2AKDM4ENPC1ALDH1A1GAA | |
| SCHEMBL14296825 | 0.86 | ALDH1A1 (0.37) | KMT2AKDM4ENPC1ALDH1A1GAA | |
| SCHEMBL4984735 | 0.84 | BRS3 (0.40) | KMT2AKDM4ENPC1ALDH1A1GAA | |
| SCHEMBL13532746 | 0.79 | MEN1 (0.42) | KMT2AKDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL4991840 | 0.78 | BRS3 (0.37) | KMT2AKDM4ENPC1ALDH1A1GAA | |
| SCHEMBL4986944 | 0.78 | TSHR (0.42) | KMT2AKDM4ENPC1ALDH1A1GAA | |
| SCHEMBL4985252 | 0.77 | KMT2A (0.39) | KMT2AKDM4ENPC1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | RENOVIS, INC. | 2008-02-14 | — | — | US | claimed |
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | RENOVIS, INC. | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX2 | KMT2A 4614/4885KDM4E 4128/4885NPC1 2233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.