Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | HPN | P05981 | 2/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7821908 | 0.88 | SRC (0.55) | CYP2D6MAPK1LMNANPY2RALDH1A1 | |
| SCHEMBL4798350 | 0.84 | KMT2A (0.44) | ALDH1A1RECQLGAAF2PRSS1 | |
| SCHEMBL4801052 | 0.84 | ALDH1A1 (0.42) | CYP2D6MAPK1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL7096179 | 0.84 | KMT2A (0.44) | LMNAALDH1A1SMN1; SMN2GAAF2 | |
| SCHEMBL20550796 | 0.84 | ALDH1A1 (0.47) | MAPK1LMNAALDH1A1NPC1MAPT | |
| SCHEMBL4796158 | 0.82 | EGFR (0.45) | CYP2D6MAPK1LMNAALDH1A1MAPT | |
| SCHEMBL4464950 | 0.82 | CYP2D6 (0.39) | CYP2D6MAPK1LMNANPY2RALDH1A1 | |
| SCHEMBL11689700 | 0.79 | NPY2R (0.50) | CYP2D6MAPK1LMNANPY2RALDH1A1 | |
| SCHEMBL19732918 | 0.78 | LMNA (0.59) | CYP2D6MAPK1LMNANPY2RALDH1A1 | |
| SCHEMBL5133327 | 0.77 | SRC (0.48) | CYP2D6MAPK1LMNAALDH1A1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4307170-A | ACID CATALYST - AZO COUPLERS PROMOTE DISCOLORATION AND BLOOM RESISTANCE | JAMES RIVER GRAPHICS, INC. (US) | 1981-12-22 | — | — | US | claimed |
| EP-3515895-A1 | COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION AND/OR FIBROSIS | Vectus Biosystems Limited (AU) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018053588-A1 | COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION AND/OR FIBROSIS | VECTUS BIOSYSTEMS LIMITED (AU) | 2018-03-29 | — | — | WO | disclosed |
| US-20080114010-A1 | Novel Substituted Imidazole Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-05-15 | — | — | US | disclosed |
| US-7301021-B2 | Substituted imidazole compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-27 | — | — | US | disclosed |
| EP-1014976-B1 | NOVEL SUBSTITUTED IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2005-03-02 | — | — | EP | disclosed |
| EP-0889726-B1 | NOVEL CYCLOALKYL SUBSTITUTED IMIDAZOLES | SMITHKLINE BEECHAM CORP (US) | 2004-09-15 | — | — | EP | disclosed |
| EP-0999842-A4 | NOVEL SUBSTITUTED IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-0935465-B1 | NOVEL SUBSTITUTED IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-04-14 | — | — | EP | disclosed |
| EP-0809499-B1 | CERTAIN 1,4,5-TRI-SUBSTITUTED IMIDAZOLE COMPOUNDS USEFUL AS CYTOKINE | SMITHKLINE BEECHAM CORP (US) | 2003-11-19 | — | — | EP | disclosed |
| WO-1997025045-A1 | NOVEL SUBSTITUTED IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-17 | — | — | WO | disclosed |
| WO-1997025048-A1 | NOVEL CYCLOALKYL SUBSTITUTED IMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-17 | — | — | WO | disclosed |
| WO-1997025047-A1 | NOVEL CYCLOALKYL SUBSTITUDED IMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-17 | — | — | WO | disclosed |
| WO-1997025046-A1 | NOVEL SUBSTITUTED IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-17 | — | — | WO | disclosed |
| US-5593992-A | CYTOKINE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-01-14 | — | — | US | disclosed |
| US-5593991-A | ANTIINFLAMMATORY, CYTOKINE INHIBITOR, CYCLOOXYGENASE INHIBITOR | SMITHKLINE BEECHAM CORPORATION | 1997-01-14 | — | — | US | disclosed |
| WO-1996040143-A1 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-12-19 | — | — | WO | disclosed |
| WO-1996021452-A1 | CERTAIN 1,4,5-TRI-SUBSTITUTED IMIDAZOLE COMPOUNDS USEFUL AS CYTOKINE | SMITHKLINE BEECHAM CORPORATION (US) | 1996-07-18 | — | — | WO | disclosed |
| WO-1996021654-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-07-18 | — | — | WO | disclosed |
| US-4307170-A | ACID CATALYST - AZO COUPLERS PROMOTE DISCOLORATION AND BLOOM RESISTANCE | JAMES RIVER GRAPHICS, INC. (US) | 1981-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114010-A1 | Novel Substituted Imidazole Compounds | CREBBP, MAPKAPK2, ATF1 | CYP2D6 4679/4885MAPK1 22/4885LMNA 3863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.