Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 6/20 | 0.46 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4988448 | 0.88 | MEN1 (0.45) | PKMAKR1C3MEN1KMT2AAKR1C1 | |
| SCHEMBL4980960 | 0.86 | SMN1; SMN2 (0.46) | PKMTSHRLMNASMN1; SMN2AKR1C3 | |
| SCHEMBL4982603 | 0.86 | SMN1; SMN2 (0.49) | PKMSMN1; SMN2AKR1C3MEN1KMT2A | |
| SCHEMBL4988327 | 0.85 | GBA1 (0.48) | PKMLMNAMEN1KMT2AGAA | |
| SCHEMBL4983020 | 0.85 | MEN1 (0.47) | PKMAKR1C3MEN1KMT2AGAA | |
| SCHEMBL4993377 | 0.85 | KMT2A (0.43) | PKMLMNAATMSMN1; SMN2AKR1C3 | |
| SCHEMBL4988642 | 0.85 | MAPT (0.43) | LMNASMN1; SMN2AKR1C3MEN1KMT2A | |
| SCHEMBL4992075 | 0.85 | CYP3A4 (0.53) | PKMTSHRLMNAHSD11B1SMN1; SMN2 | |
| SCHEMBL4987011 | 0.84 | PKM (0.46) | PKMTSHRLMNAHSD11B1SMN1; SMN2 | |
| SCHEMBL4992564 | 0.84 | MEN1 (0.47) | PKMLMNAAKR1C3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | RENOVIS, INC. | 2008-02-14 | — | — | US | claimed |
| US-7297700-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2007-11-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX2 | PKM 1098/4885MCOLN3 961/4885TSHR 3850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.