Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.55 |
| ▸ | HSD17B1 | P14061 | 7/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 7/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenol SCHEMBL27952434 | 0.86 | GABRA1 (0.55) | GABRA1GABRB2AKR1B1CYP3A4CYP2C9 | |
| SCHEMBL28617501 | 0.85 | AKR1B1 (0.55) | GABRA1GABRB2AKR1B1HSD17B1HSD17B2 | |
| SCHEMBL6537109 | 0.84 | GABRA1 (0.59) | GABRA1GABRB2AKR1B1CYP3A4CYP2C9 | |
| SCHEMBL9801818 | 0.81 | PIK3CA (0.46) | GABRA1GABRB2AKR1B1HSD17B1HSD17B2 | |
| SCHEMBL27677647 | 0.81 | GABRA1 (0.56) | GABRA1GABRB2AKR1B1CYP3A4CYP2C9 | |
| Phenol SCHEMBL28941280 | 0.80 | GABRA1 (0.60) | GABRA1GABRB2AKR1B1CYP3A4CYP2C9 | |
| SCHEMBL170787 | 0.80 | DPP4 (0.54) | GABRA1GABRB2AKR1B1KMT2AAURKA | |
| SCHEMBL9801814 | 0.80 | CYP19A1 (0.42) | GABRA1GABRB2AKR1B1HSD17B1HSD17B2 | |
| SCHEMBL28267634 | 0.79 | GABRA1 (0.48) | GABRA1GABRB2AKR1B1GAAKMT2A | |
| Biphenyl SCHEMBL7928631 | 0.78 | DPP4 (0.52) | GABRA1GABRB2AKR1B1KMT2AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
| EP-1847535-A1 | 1-(PIPERIDIN-4-YL)-1H-INDOLE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2007-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | TPH1, HTR1D, HTR1B | GABRA1 1636/4885GABRB2 2261/4885AKR1B1 317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.