Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2163244 | 0.83 | ALDH1A1 (0.46) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL20847708 | 0.82 | CYP1A2 (0.41) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL18190402 | 0.81 | CYP1A2 (0.40) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL27236092 | 0.81 | CFD (0.44) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL10925261 | 0.81 | CYP3A4 (0.40) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL20796885 | 0.79 | PNMT (0.52) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL21296470 | 0.78 | CYP3A4 (0.48) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL800062 | 0.77 | ALDH1A1 (0.39) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL22801396 | 0.76 | CYP1A2 (0.68) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL423182 | 0.76 | CYP1A2 (0.68) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338143-B2 | Enhanced production of paclitaxel and taxanes by cell cultures of Taxus species | PHYTON HOLDINGS, LLC (US) | 2012-12-25 | — | — | US | disclosed |
| US-20080108115-A1 | ENHANCED PRODUCTION OF TAXOL AND TAXANES BY CELL CULTURES OF TAXUS SPECIES | DFB BIOTECH, INCORPORATED (US) | 2008-05-08 | — | — | US | disclosed |
| EP-0954596-B1 | ENHANCED PRODUCTION OF TAXANES BY CELL CULTURES OF TAXUS SPECIES | PHYTON INC (US) | 2006-01-04 | — | — | EP | disclosed |
| EP-1538214-A1 | Enhanced production of taxanes by cell cultures of taxus species | PHYTON, INC. (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-1398384-A1 | Enhanced production of taxanes by cell cultures of taxus species | Phyton Inc. (US) | 2004-03-17 | — | — | EP | disclosed |
| EP-0954596-A1 | ENHANCED PRODUCTION OF TAXANES BY CELL CULTURES OF $i(TAXUS) SPECIES | PHYTON, INC. (US) | 1999-11-10 | — | — | EP | disclosed |
| WO-1997044476-A1 | ENHANCED PRODUCTION OF TAXANES BY CELL CULTURES OF TAXUS SPECIES | PHYTON, INC. (US) | 1997-11-27 | — | — | WO | disclosed |