Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4996922 | 0.85 | PIM2 (0.47) | PIM2RAD52PIM1CSNK2A2CSNK2A1 | |
| SCHEMBL4997813 | 0.85 | PIK3CA (0.55) | PIM2RAD52FYNPIM1CSNK2A2 | |
| SCHEMBL4997537 | 0.85 | CYP11B1 (0.46) | PIM2RAD52ALDH1A1TP53FYN | |
| SCHEMBL5003462 | 0.84 | MAPT (0.47) | HRH2HRH1HRH3NPSR1SMN1; SMN2 | |
| SCHEMBL4997181 | 0.84 | MAPT (0.47) | PIM2RAD52ALDH1A1TP53GAA | |
| SCHEMBL4997412 | 0.84 | KMT2A (0.55) | PIM2RAD52NPSR1ALDH1A1TP53 | |
| SCHEMBL5000893 | 0.84 | ABCG2 (0.52) | PIM2ALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL4992156 | 0.83 | CYP11B1 (0.49) | PIM2RAD52PIM1CYP11B1CYP11B2 | |
| SCHEMBL4995459 | 0.82 | CYP11B1 (0.48) | PIM2RAD52CYP11B1CYP11B2 | |
| SCHEMBL5000651 | 0.82 | RAD52 (0.47) | PIM2RAD52SMN1; SMN2FYNPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | HRH2 2616/4885HRH1 2393/4885HRH3 3459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.