Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4997528 | 0.85 | CHEK1 (0.65) | CYP11B1CYP11B2CHEK1 | |
| SCHEMBL4997537 | 0.82 | CYP11B1 (0.46) | CYP11B1CYP11B2DHFRPIM2RAD52 | |
| SCHEMBL4987364 | 0.82 | HRH2 (0.48) | CYP11B1CYP11B2PIM2RAD52 | |
| SCHEMBL4997813 | 0.82 | PIK3CA (0.55) | CHEK1PIM2RAD52 | |
| SCHEMBL4996922 | 0.82 | PIM2 (0.47) | CYP11B1CYP11B2PIM2RAD52HSD17B10 | |
| SCHEMBL5000655 | 0.82 | BRAF (0.50) | CYP11B1CYP11B2CHEK1DHFRPIM2 | |
| SCHEMBL4997181 | 0.81 | MAPT (0.47) | CHEK1PIM2RAD52HSD17B10 | |
| SCHEMBL5000651 | 0.79 | RAD52 (0.47) | CYP11B1CYP11B2DHFRPIM2RAD52 | |
| SCHEMBL4997532 | 0.79 | CNR2 (0.49) | CYP11B1CYP11B2DHFRPIM2RAD52 | |
| SCHEMBL4997692 | 0.79 | PIM2 (0.52) | PIM2RAD52BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | CYP11B1 132/4885CYP11B2 112/4885CHEK1 1668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.