SCHEMBL498889

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL497643	0.88	HDAC6 (0.62)	HDAC1HDAC6HDAC3HDAC2HDAC8
	SCHEMBL9130737	0.85	HDAC1 (0.56)	ESR1ESR2HDAC1HDAC6HDAC3
	SCHEMBL732990	0.80	APP (0.58)	HDAC1HDAC6HDAC3HDAC2HDAC8
	SCHEMBL12871088	0.78	ESR1 (0.71)	ESR1ESR2HDAC1HDAC6HDAC3
	SCHEMBL9133624	0.78	HDAC1 (0.51)	HDAC1HDAC6HDAC3HDAC2HDAC8
	SCHEMBL1179605	0.77	ESR1 (0.62)	ESR1ESR2HDAC1HDAC6HDAC3
	Raloxifene Core SCHEMBL2567321	0.77	ESR1 (1.00)	ESR1ESR2CA2APP
	Raloxifene Core SCHEMBL29941293	0.77	ESR1 (1.00)	ESR1ESR2CA2APP
	SCHEMBL6171301	0.77	ESR2 (0.68)	ESR1ESR2HDAC6CA2APP
	SCHEMBL1886145	0.76	HDAC1 (0.80)	HDAC1HDAC6HDAC3HDAC2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.