SCHEMBL497643

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL498889	0.88	ESR1 (0.60)	HDAC6HDAC1CA1CA2HDAC3
	SCHEMBL9130737	0.84	HDAC1 (0.56)	HDAC6HDAC1CA1CA2HDAC3
	SCHEMBL5224416	0.82	APP (0.56)	HDAC6CA1CA2NPC1ALDH1A1
	SCHEMBL3554931	0.82	KDM4E (0.56)	HDAC6HDAC1CA1CA2HDAC3
	SCHEMBL12871087	0.82	HDAC6 (0.56)	HDAC6HDAC1CA2HDAC3HDAC2
	SCHEMBL1665299	0.81	NPC1 (0.56)	HDAC6CA2NPC1ALDH1A1TP53
	SCHEMBL31310542	0.81	NPC1 (0.56)	HDAC6CA2NPC1ALDH1A1TP53
	SCHEMBL1178827	0.80	NPC1 (0.56)	HDAC6NPC1ALDH1A1TP53MAPT
	SCHEMBL7645110	0.80	CA2 (0.54)	HDAC6CA2NPC1ALDH1A1TP53
	SCHEMBL9133624	0.79	HDAC1 (0.51)	HDAC6HDAC1HDAC3HDAC2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.