Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CLPP | Q16740 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4992362 | 0.88 | LIMK1 (0.48) | LIMK1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4992461 | 0.87 | LIMK1 (0.47) | LIMK1ALDH1A1KDM4ECLPPMEN1 | |
| SCHEMBL4988556 | 0.87 | LIMK1 (0.47) | LIMK1ALDH1A1KDM4ECLPPMEN1 | |
| SCHEMBL4982960 | 0.86 | LIMK1 (0.61) | LIMK1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4980855 | 0.86 | LIMK1 (0.45) | LIMK1LMNAMEN1KMT2A | |
| SCHEMBL4989375 | 0.86 | HSP90AB1 (0.46) | LIMK1LMNAALDH1A1KDM4EMEN1 | |
| SCHEMBL4989472 | 0.86 | LIMK1 (0.42) | LIMK1LMNAMEN1KMT2ADRD4 | |
| SCHEMBL4985337 | 0.86 | DHFR (0.52) | LIMK1CLPPDRD2DRD4DRD3 | |
| SCHEMBL4985467 | 0.85 | LIMK1 (0.48) | LIMK1CLPPMEN1KMT2ADRD2 | |
| SCHEMBL4986127 | 0.85 | LIMK1 (0.47) | LIMK1ALDH1A1KDM4ECLPPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | RENOVIS, INC. | 2008-02-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX2 | LIMK1 1960/4885LMNA 1911/4885POLB 3676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.