Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 19/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4990663 | 0.83 | TRPV1 (0.45) | TRPV1MAOAKCNH2MAPK3LRRK2 | |
| SCHEMBL4989164 | 0.81 | TRPV1 (0.56) | TRPV1MAOAKCNH2MAPK3 | |
| SCHEMBL4993937 | 0.78 | TRPV1 (0.60) | TRPV1MAPK3 | |
| SCHEMBL14134930 | 0.77 | TRPV1 (0.36) | TRPV1MAOAKCNH2 | |
| SCHEMBL4990699 | 0.77 | TRPV1 (0.54) | TRPV1MAOAKCNH2MAPK3 | |
| SCHEMBL4986959 | 0.76 | TRPV1 (0.78) | TRPV1MAPK3 | |
| SCHEMBL5117359 | 0.76 | TRPV1 (0.38) | TRPV1MAOAKCNH2 | |
| SCHEMBL4990296 | 0.75 | TRPV1 (0.50) | TRPV1MAPK3LRRK2 | |
| SCHEMBL4994198 | 0.73 | TRPV1 (0.44) | TRPV1MAOAKCNH2 | |
| SCHEMBL4991837 | 0.73 | TRPV1 (0.76) | TRPV1MAOAKCNH2MAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080175794-A1 | Substituted Pyridazinyl- and Pyrimidinyl-Quinolin-4-Ylamine Analogues | NEUROGEN CORPORATION (US) | 2008-07-24 | — | — | US | disclosed |
| US-20080175794-A1 | Substituted Pyridazinyl- and Pyrimidinyl-Quinolin-4-Ylamine Analogues | NEUROGEN CORPORATION (US) | 2008-07-24 | — | — | US | disclosed |
| US-20080175794-A1 | Substituted Pyridazinyl- and Pyrimidinyl-Quinolin-4-Ylamine Analogues | NEUROGEN CORPORATION (US) | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080175794-A1 | Substituted Pyridazinyl- and Pyrimidinyl-Quinolin-4-Ylamine Analogues | PIGS, HRH4, GPR68 | TRPV1 199/4885MAOA 1216/4885KCNH2 2693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.