Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MMP2 | P08253 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | CCR1 | P32246 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.54 |
| ▸ | CCR5 | P51681 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29856020 | 1.00 | KDM4E (0.54) | KDM4EMMP2TSHRMAPTHTT | |
| SCHEMBL25802198 | 0.80 | KDM4E (0.45) | KDM4EMMP2TSHRMAPTHTT | |
| SCHEMBL31261655 | 0.79 | KDM4E (0.54) | KDM4EMMP2TSHRMAPTHTT | |
| SCHEMBL7344355 | 0.79 | KDM4E (0.54) | KDM4EMMP2TSHRMAPTHTT | |
| SCHEMBL30003476 | 0.79 | TSHR (0.55) | KDM4EMMP2TSHRMAPTHTT | |
| SCHEMBL7424652 | 0.79 | KDM4E (0.54) | KDM4EMMP2TSHRMAPTHTT | |
| SCHEMBL216373 | 0.79 | KDM4E (0.54) | KDM4EMMP2TSHRMAPTHTT | |
| SCHEMBL19303228 | 0.79 | KDM4E (0.54) | KDM4EMMP2TSHRMAPTHTT | |
| SCHEMBL7372603 | 0.79 | PSMD14 (0.55) | KDM4EMMP2TSHRMAPTHTT | |
| SCHEMBL895544 | 0.79 | MMP2 (0.54) | KDM4EMMP2TSHRMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108314647-A | A kind of preparation method of quinoline -2- formic acid and quinoline -2- formic acid derivates | 华中科技大学 | 2018-07-24 | — | — | CN | claimed |
| CN-112174887-B | Method for preparing 8-quinoline carboxylic acid and derivatives thereof | 江苏快达农化股份有限公司 | 2022-08-23 | — | — | CN | disclosed |
| CN-112174887-A | Method for preparing 8-quinoline carboxylic acid and derivatives thereof | 江苏快达农化股份有限公司 | 2021-01-05 | — | — | CN | disclosed |
| CN-109173602-A | A kind of circulation utilization method of the nitrous oxides exhaust gas generated in dichloro quinolinic acid synthesis | 华东理工大学 | 2019-01-11 | — | — | CN | disclosed |
| CN-105829294-B | The quinolyl conditioning agent of ROR- γ-T being connect with methylene | 詹森药业有限公司 | 2018-11-09 | — | — | CN | disclosed |
| EP-3330262-A1 | HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DIODE CONTAINING SAME | LG Chem, Ltd. (KR) | 2018-06-06 | — | — | EP | disclosed |
| EP-3260438-A1 | DOUBLE-SPIRO TYPE COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE CONTAINING SAME | LG Chem, Ltd. (KR) | 2017-12-27 | — | — | EP | disclosed |
| CN-102942524-B | Preparation method of quinoline derivative | BEIJING VAGEAN TECHNOLOGY CO LTD | 2014-12-31 | — | — | CN | disclosed |
| CN-102942524-A | Preparation method of quinoline derivative | BEIJING VAGEAN SCIENCE & TECHNOLOGY CO LTD | 2013-02-27 | — | — | CN | disclosed |
| US-7384958-B2 | Quinoline inhibitors of cGMP phosphodiesterase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-10 | — | — | US | disclosed |
| WO-2001081316-A2 | SUBSTITUTED PHENYL FARNESYLTRANSFERASE INHIBITORS | ABBOTT LABORATORIES (US) | 2001-11-01 | — | — | WO | disclosed |
| CN-1316991-A | Azetidine derivatives, preparation and medicines containing them | AVENTIS PHARMA SA (FR) | 2001-10-10 | — | — | CN | disclosed |
| EP-1112251-A1 | AZETIDINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | Aventis Pharma S.A. (FR) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000015609-A1 | AZETIDINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA S.A. (FR) | 2000-03-23 | — | — | WO | disclosed |
| US-5202336-A | Lipoxygenase inhibitors | BAYER AKTIENGESELLSCHAFT (DE) | 1993-04-13 | — | — | US | disclosed |
| US-5093340-A | Lipoxygenase enzyme inhibitors, antithrombolytic agents | BAYER AKTIENGESELLSCHAFT (DE) | 1992-03-03 | — | — | US | disclosed |
| US-5070096-A | ANTICOAGULANTS, LIPOXYGENASE INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 1991-12-03 | — | — | US | disclosed |
| EP-0261539-B1 | SUBSTITUTED PHENYL-SULPHON AMIDES | BAYER AG (DE) | 1991-03-06 | — | — | EP | disclosed |
| EP-0261539-A2 | Substituted phenyl-sulphon amides | BAYER AG (DE) | 1988-03-30 | — | — | EP | disclosed |
| US-3956420-A | CPOLYOLEFIN COMPOSITION FOR ELECTRICAL INSULATIONFERROCENE, 8-SUBSTITUTED QUINOLINE | DAINICHI-NIPPON CABLES, LTD. (JA) | 1976-05-11 | — | — | US | disclosed |