Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 2/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 7/20 | 0.43 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4986738 | 0.90 | HSP90AB1 (0.45) | MAPTHSP90AB1 | |
| SCHEMBL4985162 | 0.88 | KDM4E (0.49) | — | |
| SCHEMBL4988442 | 0.87 | ABCB1 (0.39) | GRM2MAPTHSP90AB1 | |
| SCHEMBL4982983 | 0.86 | GRM2 (0.41) | GRM2 | |
| SCHEMBL4988135 | 0.86 | GRM2 (0.37) | GRM2 | |
| SCHEMBL4985321 | 0.84 | CFTR (0.44) | GRM2MAPT | |
| SCHEMBL4984986 | 0.83 | GRM2 (0.43) | GRM2MAPT | |
| SCHEMBL4985028 | 0.83 | KDM4E (0.45) | GRM2MAPT | |
| SCHEMBL4982516 | 0.82 | DHFR (0.45) | GRM2 | |
| SCHEMBL4988672 | 0.82 | GRM2 (0.43) | GRM2IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | RENOVIS, INC. | 2008-02-14 | — | — | US | claimed |
| US-7297700-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2007-11-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX2 | MTNR1B 444/4885GRM2 332/4885GPR6 80/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.