SCHEMBL499086

SCHEMBL499086

CCc1cc(C(=O)O)c(C)c(C)c1N

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.48
KMT2A Q03164 5/20 0.48
MEN1 O00255 3/20 0.48
TDP1 Q9NUW8 3/20 0.48
GABRP O00591 5/20 0.47
GABRD O14764 5/20 0.47
GABRA1 P14867 5/20 0.47
GABRB1 P18505 5/20 0.47
GABRG2 P18507 5/20 0.47
GABRB3 P28472 5/20 0.47
GABRA5 P31644 5/20 0.47
GABRA3 P34903 5/20 0.47
GABRA2 P47869 5/20 0.47
GABRB2 P47870 5/20 0.47
GABRA4 P48169 5/20 0.47
GABRE P78334 5/20 0.47
GABRA6 Q16445 5/20 0.47
GABRG1 Q8N1C3 5/20 0.47
GABRG3 Q99928 5/20 0.47
GABRQ Q9UN88 5/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27659507 0.85 KDM4E (0.46) KDM4EKMT2AMEN1TDP1GABRP
SCHEMBL6371440 0.85 KDM4E (0.48) KDM4EKMT2AMEN1TDP1GABRP
SCHEMBL27478567 0.84 KDM4E (0.44) KDM4EKMT2AMEN1TDP1GABRP
SCHEMBL1245179 0.83 GABRP (0.49) KDM4EKMT2AMEN1TDP1GABRP
SCHEMBL128456 0.82 GABRP (0.48) KDM4EKMT2AMEN1TDP1GABRP
SCHEMBL5274832 0.82 KDM4E (0.44) KDM4EKMT2AMEN1TDP1GABRP
SCHEMBL28446424 0.78 KDM4E (0.42) KDM4EKMT2AMEN1TDP1GABRP
SCHEMBL10988751 0.77 GABRP (0.47) KDM4EKMT2AMEN1TDP1GABRP
SCHEMBL27589178 0.77 GABRP (0.47) KDM4EKMT2AMEN1TDP1GABRP
SCHEMBL5986239 0.76 ALDH1A1 (0.37) KDM4EKMT2AMEN1TDP1GABRP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10322069-B2 Restorative resin compositions and methods of use THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2019-06-18 US claimed
US-20170020789-A1 RESTORATIVE RESIN COMPOSITIONS AND METHODS OF USE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2017-01-26 US claimed
WO-2015157329-A1 RESTORATIVE RESIN COMPOSITIONS AND METHODS OF USE THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2015-10-15 WO claimed
US-8106110-B2 first portion: bisphenol diglycidylmethacrylate phosphate, 2-hydroxyethylmethacrylate, biphenyl dimethacrylate, dipentaerythritol pentaacrylate, bisphenyl A diglycidylmethacrylate, ethyl-4-dimethyl-aminobenzoate and camphorquinone; second portion: deionized water, aryl sulfinate, thymol blue, and ethanol BISCO, INC. (US) 2012-01-31 US claimed
EP-2114357-A1 DUAL APPLICATION MODE SELF-ETCH DENTAL ADHESIVES COMPATIBLE WITH SELF-CURED AND DUAL-CURED COMPOSITES Bisco, Inc. (US) 2009-11-11 EP claimed
WO-2008094923-A1 DUAL APPLICATION MODE SELF-ETCH DENTAL ADHESIVES COMPATIBLE WITH SELF-CURED AND DUAL-CURED COMPOSITES BISCO, INC. (US) 2008-08-07 WO claimed
US-20080182922-A1 Dual Application Mode Self-Etch Dental Adhesives Compatible with Self-Cured and Dual-Cured Composites BISCO, INC. (US) 2008-07-31 US claimed
WO-2003013379-A2 DENTAL COMPOSITIONS B.J.M. LABORATORIES LTD. (IL) 2003-02-20 WO claimed
EP-0140140-B1 DENTAL COMPOSITE AND PORCELAIN REPAIR DEN-MAT CORPORATION (US) 1991-04-10 EP claimed
US-11548964-B2 One-part curable soft feel coatings ARKEMA FRANCE (FR) 2023-01-10 US disclosed
US-20210252186-A1 AN ADHESIVE LAYERED MATRIX AND USES THEREOF NURAMI MEDICAL LTD. (IL) 2021-08-19 US disclosed
EP-3802111-A1 AN ADHESIVE LAYERED MATRIX AND USES THEREOF Nurami Medical Ltd (IL) 2021-04-14 EP disclosed
CN-112368142-A Adhesive layered substrates and uses thereof 纽拉米医学有限公司 2021-02-12 CN disclosed
EP-2814610-B1 MICROSTRUCTURED POLYMER DEVICES STRATEC CONSUMABLES GmbH (AT) 2020-08-19 EP disclosed
US-20060130701-A1 Hydrolysis-stable self-etching single-component dental adhesive IVOCLAR VIVADENT AG (LI) 2006-06-22 US disclosed
WO-2003013379-A2 DENTAL COMPOSITIONS B.J.M. LABORATORIES LTD. (IL) 2003-02-20 WO disclosed
EP-0563085-B1 NOVEL COMPOSITIONS BEECHAM GROUP PLC (GB) 1996-11-27 EP disclosed
EP-0140140-B1 DENTAL COMPOSITE AND PORCELAIN REPAIR DEN-MAT CORPORATION (US) 1991-04-10 EP disclosed
US-4268659-A ESTERIFICATION WITH ACRYLIC OR METHACRYLIC ESTERS CONTAINING AN OXIRANE RING HERBERTS GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1981-05-19 US disclosed
EP-0017798-A1 Modified polyester imides curable by high energy radiation, process for their production and their use in the insulation of electric wires Herberts Gesellschaft mit beschränkter Haftung (DE) 1980-10-29 EP disclosed